LEADER 02783nam  2200421z- 450 
001 9910136803103321
005 20231214133720.0
035   $a(CKB)3710000000631102
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58581
035   $a(EXLCZ)993710000000631102
100   $a20202102d2015      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aThe Role of Glia in Plasticity and Behavior
210   $cFrontiers Media SA$d2015
215   $a1 electronic resource (104 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-690-9 
330   $aGlial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
610   $aCerebellum
610   $aC. elegans
610   $aAstrocytes
610   $aDREADD
610   $aCortex
610   $aplasticity
610   $aGq
610   $aBehavior
610   $aglia
610   $aHippocampus
700   $aTycho Hoogland$4auth$01332333
702   $aParpura$b Vladimir$f1964-$4auth
906   $aBOOK
912   $a9910136803103321
996   $aThe Role of Glia in Plasticity and Behavior$93040850
997   $aUNINA