LEADER 04685nam 2200721 450 001 9910136802703321 005 20240118021642.0 024 7 $a10.3389/978-2-88919-695-1 035 $a(CKB)3710000000631104 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42444 035 $a(EXLCZ)993710000000631104 100 $a20160411d2015uuuu fy| 0 101 0 $aeng 135 $aurc|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBreaking the cycle $eattacking the malaria parasite in the liver /$fedited by Ute Frevert, Urszula Krzych, Thomas L. Richie 210 $cFrontiers Media SA$d2015 210 1$a[Place of publication not identified] :$cFrontiers Media SA,$d2015. 215 $a1 online resource (173 pages) $cillustrations, charts; digital, PDF file(s) 225 0 $aFrontiers research topics 225 1 $aFrontiers in Human Neuroscience,$x1664-8714 311 $a2-88919-695-X 320 $aIncludes bibliographical references. 330 3 $aDespite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans ? the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center?s DNA prime / Ad boost vaccine, Sanaria, Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Nijmegen Medical Centre?s chemoprophylaxis with sporozoites vaccine. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host?s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world?s population constantly at risk of malaria. 410 0$aFrontiers in Human Neuroscience,$x1664-8714. 606 $aPlasmodium falciparum 606 $aMalaria$xImmunological aspects 606 $aMalaria$xPrevention 606 $aMalaria$xResearch 606 $aLiver$xImmunology 606 $aLiver$xParasites 606 $aHepatology 606 $aPlasmodis$2lemac 610 $aCD8 T cell 610 $aPlasmodium 610 $aB cell 610 $aantigen-presenting cell 610 $aimmune response 610 $aMalaria vaccine 610 $ahepatic microenvironment 610 $aCD4 T cell 610 $aanimal model 610 $aadjuvants 615 0$aPlasmodium falciparum. 615 0$aMalaria$xImmunological aspects. 615 0$aMalaria$xPrevention. 615 0$aMalaria$xResearch. 615 0$aLiver$xImmunology. 615 0$aLiver$xParasites. 615 0$aHepatology. 615 7$aPlasmodis 700 $aRichie$b Thomas$4auth$01461104 702 $aFrevert$b Ute 702 $aKrzych$b Urszula 702 $aRichie$b Thomas$4auth 801 0$bUkMaJRU 801 2$bNZ-WeVUL 906 $aBOOK 912 $a9910136802703321 996 $aBreaking the cycle$93663112 997 $aUNINA