LEADER 02880nam  2200433z- 450 
001 9910136802503321
005 20231214133659.0
035   $a(CKB)3710000000631105
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57138
035   $a(EXLCZ)993710000000631105
100   $a20202102d2015      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aProgenitor diversity and neural cell specification in the central nervous system
210   $cFrontiers Media SA$d2015
215   $a1 electronic resource (107 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-683-6 
330   $aThe central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential.
610   $aFate Restriction
610   $aCentral Nervous System
610   $aNeurons
610   $aAstrocytes
610   $aExtrinsic Signals
610   $aneural progenitors
610   $aspecification
610   $aTranscription Factors
610   $aoligodendrocytes
610   $aneurogenic niches
700   $aMarcos R. Costa$4auth$01280857
702   $aCecilia Hedin-Pereira$4auth
702   $aCaroline Rouaux$4auth
906   $aBOOK
912   $a9910136802503321
996   $aProgenitor diversity and neural cell specification in the central nervous system$93017544
997   $aUNINA