LEADER 02125nam  2200481z- 450 
001 9910136802403321
005 20210211
035   $a(CKB)3710000000631106
035   $a(oapen)doab55788
035   $a(EXLCZ)993710000000631106
100   $a20202102d2015      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aPathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
210   $cFrontiers Media SA$d2015
215   $a1 online resource (248 p.)
225 1 $aFrontiers Research Topics
311 08$a9782889196845 
311 08$a2889196844 
330   $aLoss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.
517   $aPathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy
606   $aNeurosciences$2bicssc
610   $aAging sarcopenia
610   $aAnimal Models
610   $aApoptosis
610   $aAutophagy
610   $aMitochondrial dysfunction
610   $amuscle imaging
610   $amuscular dystrophy
610   $asatellite cells
610   $askeletal muscle
610   $atherapy
615  7$aNeurosciences
700   $aPaolo Bonaldo$4auth$01322469
702   $aLuciano Merlini$4auth
702   $aEmanuele Marzetti$4auth
906   $aBOOK
912   $a9910136802403321
996   $aPathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach$93035042
997   $aUNINA