LEADER 02479nam  2200433z- 450 
001 9910136800603321
005 20231214132853.0
035   $a(CKB)3710000000631116
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55086
035   $a(EXLCZ)993710000000631116
100   $a20202102d2016      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aObesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors
210   $cFrontiers Media SA$d2016
215   $a1 electronic resource (45 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-747-6 
330   $aFood intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled receptors (GPCRs) that act as FFA receptors (FFARs) have been identified; GPR40/FFAR1, GPR119, and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain FFAs. GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain FFAs. These FFARs have come to be regarded as new drug targets for metabolic disorder such as obesity and type 2 diabetes, because a number of pharmacological and physiological studies have shown that these receptors are primarily involved in the energy metabolism in various tissues; insulin secretion, gastrointestinal hormone secretion, adipokine secretion, regulation of inflammation, regulation of autonomic nervous system, relation to gut microbiota, and so on. This Research Topic provides a comprehensive overview of the energy regulation by free fatty acid receptors and a new prospect for treatment of metabolic disorder such as obesity and type 2 diabetes.
517   $aObesity and Diabetes
610   $amicrobiota
610   $aObesity
610   $aGPCRs
610   $aInsulin Resistance
610   $aFFARs
610   $aSCFAs
610   $afree fatty acids
610   $aMetabolism
610   $adiabetes
610   $aenergy homeostasis
700   $aAtsuhiko Ichimura$4auth$01287882
702   $aIkuo Kimura$4auth
906   $aBOOK
912   $a9910136800603321
996   $aObesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors$93020522
997   $aUNINA