LEADER 04640oam 2200505 450 001 9910136799603321 005 20230808192400.0 035 $a(CKB)3710000000631126 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44313 035 $a(EXLCZ)993710000000631126 100 $a20160411h20162016 fu 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCrosstalk between the osteogenic and neurogenic stem cell niches$b[electronic resource] $ehow far are they from each other? /$fedited by: Wanda Lattanzi and Maria Concetta Geloso 210 $cFrontiers Media SA$d2016 210 1$aLausanne, Switzerland :$cFrontiers Media SA,$d2016. 210 4$dİ2016 215 $a1 online resource (102 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $a"Published in Frontiers in Cellular Neuroscience". 311 $a2-88919-777-8 320 $aIncludes bibliographical references. 330 $aSomatic stem cells reside in definite compartments, known as ?niches?, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organ, including brain and heart. Mesenchymal stem cells (MSCs) are multipotent cells residing in the connective stroma of adult tissues and organs, endowed with outstanding plasticity and trophic features. Strictly-defined MSCs have been originally described as fibroblastoid cells in the bone marrow stroma, able to give rise to differentiated bone cells. Thereafter, additional tissue sources, including adipose tissue, skin, muscle, among others, have been exploited for isolating cell populations that share MSC-like biological features. MSCs are able to differentiate along multiple mesodermal lineages and are believed to represent the key somatic stem cell within the skeletogenic niche, being conceptually able to produce any tissue included within a mature skeletal segment (bone, cartilage, blood vessels, adipose tissue, and supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal lineages, including neurons, has been strongly argued. No clear scientific clue has indeed proved the possibility to achieve a functional non-mesordermal phenotype upon MSCs in vitro induction or in vivo inoculation. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors? lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. Beyond embryo stage, neurogenesis persists throughout postnatal life in the subventricular zone (SVZ) of the forebrain lateral ventricles and in the subgranular zone of the hippocampus of adult brain. Here the principal reservoirs of adult neural stem cells reside in specific niches and generate neurons and glial cells to sustain the turnover of selected brain compartments. Studying these reservoirs is useful to gather information on the specialized cellular microenvironments and molecular signals that are needed to maintain neural stem cells in vivo, regulating the fine equilibrium between proliferation and differentiation, acting on the switch between symmetrical and asymmetrical cell division. Based on this contemporary background, this Research Topic wish to provide an in-depth revision of the state of the art on relevant scientific milestones addressing the differences and possible interconnections and overlaps, between the osteogenic and the neurogenic niche, clarifying the questioned issue of neuronal transdifferentiation of somatic stem cells. 606 $aNeuroscience 610 $aNeuropeptide Y 610 $aStem Cell Niche 610 $aMesenchymal Stromal Cells 610 $aNeural Stem Cells 610 $aRegenerative Medicine 610 $aWnt/beta-catenin signaling 610 $aBone Marrow 610 $aNeural Crest 610 $aRUNX2 615 0$aNeuroscience. 700 $aMaria Concetta Geloso$4auth$01377633 702 $aLattanzi$b Wanda 702 $aGeloso$b Maria Concetta 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136799603321 996 $aCrosstalk between the osteogenic and neurogenic stem cell niches$93415135 997 $aUNINA LEADER 02670nam0 2200505 i 450 001 VAN0127258 005 20230628090202.856 017 70$2N$a9781493998104 100 $a20200303d2019 |0itac50 ba 101 $aeng 102 $aUS 105 $a|||| ||||| 200 1 $aMathematical Modelling and Biomechanics of the Brain$fCorina Drapaca, Siv Sivaloganathan 210 $aNew York$cFields institute for research in the mathematical sciences$cSpringer$d2019 215 $ax, 155 p.$d24 cm 410 1$1001VAN0053229$12001 $aFields Institute monographs$fThe Fields institute for research in mathematical sciences$1210 $aProvidence$cAmerican mathematical society$1300 $aDal 2013 il luogo e l'editore variano in: New York : Springer$v37 500 1$3VAN0237067$aMathematical Modelling and Biomechanics of the Brain$91733828 606 $a35Q35$xPDEs in connection with fluid mechanics [MSC 2020]$3VANC022935$2MF 606 $a78A70$xBiological applications of optics and electromagnetic theory [MSC 2020]$3VANC023169$2MF 606 $a92Cxx$xPhysiological, cellular and medical topics [MSC 2020]$3VANC024650$2MF 606 $a92C50$xMedical applications (general) [MSC 2020]$3VANC027825$2MF 606 $a92C10$xBiomechanics [MSC 2020]$3VANC030904$2MF 606 $a74L15$xBiomechanical solid mechanics [MSC 200]$3VANC031207$2MF 606 $a74Fxx$xCoupling of solid mechanics with other effects [MSC 2020]$3VANC031208$2MF 606 $a76Zxx$xBiological fluid mechanics [MSC 2020]$3VANC035187$2MF 610 $aBrain cancer$9KW:K 610 $aBrain science$9KW:K 610 $aBrain trauma$9KW:K 610 $aHydrocephalus$9KW:K 610 $aMathematical medicine$9KW:K 610 $aMathematical oncology$9KW:K 610 $aMechanics of deformable solids$9KW:K 620 $aUS$dNew York$3VANL000011 700 1$aDrapaca$bCorina$3VANV098699$0781831 701 1$aSivaloganathan$bSiv$3VANV098700$0781832 712 $aFields Institute for Research in the Mathematical Sciences$3VANV114657$4650 712 $aSpringer $3VANV108073$4650 801 $aIT$bSOL$c20240614$gRICA 856 4 $uhttp://doi.org/10.1007/978-1-4939-9810-4$zE-book ? 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