LEADER 03584oam 2200469 450 001 9910136799203321 005 20230621135411.0 010 $a9782889197507 (ebook) 035 $a(CKB)3710000000631130 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42834 035 $a(EXLCZ)993710000000631130 100 $a20191103c2016uuuu uu 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCD1- and MR1-restricted T cells in antimicrobial immunity$b[electronic resource] /$fedited by S.M. Mansour Haeryfar and Thierry Mallevaey 210 $cFrontiers Media SA$d2016 210 1$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (189 pages) $ccolour illustrations 225 1 $aFrontiers Research Topics 320 $aIncludes bibliographical references. 330 $aCell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ?unconventional?, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ?memory-like? properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic. 606 $aCellular biology 610 $aCD1 610 $aMAIT cell 610 $ainfection 610 $aimmunopathology 610 $amicrobes 610 $ainflammation 610 $ainnate-like T cells 610 $aimmunity 610 $aNKT cell 610 $aMR1 615 0$aCellular biology. 700 $aS.M. Mansour Haeryfar$4auth$01364000 702 $aThierry Mallevaey$4auth 801 0$bUkMaJRU 912 $a9910136799203321 996 $aCD1- and MR1-restricted T cells in antimicrobial immunity$93385073 997 $aUNINA