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035   $a(CKB)3710000000631132
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40966
035   $a(EXLCZ)993710000000631132
100   $a20160411d2015uuuu  fy|            0
101 0 $aeng
135   $aurcu#---uuuuu
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aAntimicrobial peptides and Complement - maximising the  inflammatory response$b[electronic resource] /$fedited by: Cordula M. Stover
210   $cFrontiers Media SA$d2015
210 31$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2015.
215   $a1 online resource (157 pages) $cillustrations; digital, PDF file(s)
225 0 $aFrontiers research topics
225 1 $aFrontiers in Immunology
311   $a2-88919-737-9 
320   $aIncludes bibliographical references.
330 3 $aAntimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response.
410  0$aFrontiers in Immunology.
606   $aImmunology
606   $aPeptide antibiotics
606   $aComplement System Proteins$ximmunology
610   $aDisease
610   $aregulation
610   $aHealth
610   $asystem-specific
610   $acomplement
610   $aantimicrobial peptides
615  0$aImmunology.
615  0$aPeptide antibiotics.
615  2$aComplement System Proteins$ximmunology.
700   $aCordula M. Stover$4auth$01364628
702   $aStover$b Cordula M.
801  2$bUkMaJRU
906   $aBOOK
912   $a9910136799003321
996   $aAntimicrobial peptides and Complement - maximising the inflammatory response$93386067
997   $aUNINA