LEADER 04222nam 2200469z- 450 001 9910136798903321 005 20210211 035 $a(CKB)3710000000631133 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56987 035 $a(oapen)doab56987 035 $a(EXLCZ)993710000000631133 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPrinciples Underlying Post-Stroke Recovery of Upper Extremity Sensorimotor Function - A Neuroimaging Perspective 210 $cFrontiers Media SA$d2016 215 $a1 online resource (153 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-767-0 330 $aNeuroimaging post-stroke has the potential to uncover underlying principles of disturbed hand function and recovery characterizing defined patient groups, including their long term course as well as individual variations. The methods comprise functional magnetic resonance imaging (MRI) measuring task related activation as well as resting state. Functional MRI may be complemented by arterial spin labeling (ASL) MRI to investigate slowly varying blood flow and associated changes in brain function. For structural MRI robust and accurate computational anatomical methods like voxel-based morphometry and surface based techniques are available. The investigation of the connectivity among brain regions and disruption after stroke is facilitated by diffusion tensor imaging (DTI). Intra- and interhemispheric coherence may be studied by electromagnetic techniques such as electroencephalography and transcranial magnetic stimulation. Consecutive phases of stroke recovery (acute, subacute, early chronic and late chronic stages) are each distinguished by intrinsic processes. The site and size of lesions entail partially different functional implications. New strategies to establish functional specificity of a lesion site include calculating contrast images between patients exhibiting a specific disorder and control subjects without the disorder. Large-size lesions often imply poor cerebral blood flow which impedes recovery significantly and possibly interferes with BOLD response of functional MRI. Thus, depending on the site and size of the infarct lesion the patterns of recovery will vary. These include recovery sensu stricto in the perilesional area, intrinsic compensatory mechanisms using alternative cortical and subcortical pathways, or behavioral compensatory strategies e.g. by using the non-affected limb. In this context, behavioral and neuroimaging measures should be developed and employed to delineate aspects of learning during recovery. Of special interest in recovery of hand paresis is the interplay between sensory and motor areas in the posterior parietal cortex involved during reaching and fine motor skills as well as the interaction with the contralesional hemisphere. The dominant disability should be characterized, from the level of elementary to hierarchically higher processes such as neglect, apraxia and motor planning. In summary, this Research Topic covers new trends in state of the art neuroimaging of stroke during recovery from upper limb paresis. Integration of behavioral and neuroimaging findings in probabilistic brain atlases will further advance knowledge about stroke recovery. 606 $aNeurology and clinical neurophysiology$2bicssc 610 $acomputational biophysical modeling 610 $amotor control 610 $aMotor Imagery 610 $amultimodal neuroimaging 610 $anetwork reorganization 610 $aNeurorehabilitation 610 $aperilesional plasticity 610 $aSomatosensory Disorders 610 $astroke recovery 610 $astructural covariance 615 7$aNeurology and clinical neurophysiology 700 $aRudiger J. Seitz$4auth$01280922 702 $aBruno J. Weder$4auth 702 $aRoland Wiest$4auth 906 $aBOOK 912 $a9910136798903321 996 $aPrinciples Underlying Post-Stroke Recovery of Upper Extremity Sensorimotor Function - A Neuroimaging Perspective$93017673 997 $aUNINA