LEADER 02477nam  2200469z- 450 
001 9910136797903321
005 20210212
035   $a(CKB)3710000000631143
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58575
035   $a(oapen)doab58575
035   $a(EXLCZ)993710000000631143
100   $a20202102d2016      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aThe Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
210   $cFrontiers Media SA$d2016
215   $a1 online resource (107 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88919-770-0 
330   $aThe focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mTECs). It includes one Editorial and 12 other excellent contributions in the format of mini reviews or original research papers covering one or more of these aspects: promiscuous gene expression (PGE), epigenetics, miRNAs, association of the Aire gene and miRNAs, thymocyte-TEC interaction, coxsackievirus and type 1 diabetes, exosomes in the thymus, thymic crosstalk, thymic B cells, T cell development, chemokines and migration of T cells, miRNAs and the thymic atrophy, cell-cell interactions, and thymus ontogeny. Authors raised hypothesis, discuss concepts, and show open questions. The remaining important issues to resolve questions within the central tolerance research are briefly discussed below.
606   $aMedicine$2bicssc
610   $aAire gene
610   $acell-cell interaction
610   $aCentral Tolerance
610   $aChemokines
610   $amicroRNA
610   $apromiscuous gene expression
610   $aThymic B cell
610   $athymic crosstalk
610   $athymocyte
610   $aThymus
615  7$aMedicine
700   $aGeraldo Aleixo Passos$4auth$01279442
702   $aErnna Herida Oliveira$4auth
702   $aDaniella Areas Mendes-da-Cruz$4auth
906   $aBOOK
912   $a9910136797903321
996   $aThe Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance$93015381
997   $aUNINA