LEADER 03656oam 22005291 450 001 9910136797703321 005 20240619212325.0 035 $a(CKB)3710000000631145 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42243 035 $a(EXLCZ)993710000000631145 100 $a20160411d2016 fy 0 101 0 $aeng 135 $aurmn#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiology-driven targeted therapy of pediatric soft-tissue and bone tumors $ecurrent opportunities and future challenges /$fedited by Thomas G. P. Grünewald and Simone Fulda 210 $cFrontiers Media SA$d2016 210 1$aLausanne, Switzerland :$cFrontiers Media SA,$d2016. 210 4$dİ2016 215 $a1 online resource (147 pages) $cillustrations, charts; digital, PDF file(s) 225 0 $aFrontiers Research Topics 311 $a2-88919-819-7 320 $aIncludes bibliographical references. 330 $aRecent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of ?omics? technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the ?Pediatric Cancer Translational Genomics? conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on ?Molecular Biology and Innovative Therapies in Sarcomas? (Pultusk, Poland, 2012), and the AACR special meeting on ?Pediatric Cancer at the Crossroads ? Translating Discovery into Improved Outcomes? (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists. 606 $aOncology$xResearch 606 $aCancer in children$xTreatment 610 $atargeted therapy 610 $aTranslational research 610 $aEwing sarcoma 610 $aSarcoma 610 $apediatric oncology 610 $aOsteosarcoma 610 $aImmunotherapy 610 $abone tumor 610 $aRhabdomyosarcoma 610 $aepithelioid sarcoma 615 0$aOncology$xResearch. 615 0$aCancer in children$xTreatment. 700 $aSimone Fulda$4auth$01340923 702 $aGrünewald$b Thomas 702 $aFulda$b Simone 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136797703321 996 $aBiology-driven targeted therapy of pediatric soft-tissue and bone tumors$93409322 997 $aUNINA