LEADER 04711nam 2200613 450 001 9910467824203321 005 20200520144314.0 010 $a3-11-053727-3 010 $a3-11-053877-6 024 7 $a10.1515/9783110538779 035 $a(CKB)4340000000203623 035 $a(MiAaPQ)EBC5049517 035 $a(DE-B1597)478856 035 $a(OCoLC)1004874786 035 $a(DE-B1597)9783110538779 035 $a(PPN)219912009 035 $a(Au-PeEL)EBL5049517 035 $a(CaPaEBR)ebr11443164 035 $a(CaONFJC)MIL1036843 035 $a(OCoLC)1004544759 035 $a(EXLCZ)994340000000203623 100 $a20171016h20172017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aClassification from antiquity to modern times $esources, methods, and theories from an interdisciplinary perspective /$fedited by Tanja Pommerening and Walter Bisang 210 1$aBerlin, [Germany] ;$aBoston, [Massachusetts] :$cDe Gruyter,$d2017. 210 4$d©2017 215 $a1 online resource (350 pages) $cillustrations 311 $a3-11-053612-9 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tPreface -- $tContents -- $tClassification and Categorization through Time -- $tCategorization and Explanation of the World in Hesiod?s Theogony -- $tWhat is a horse? Lexical Acculturation and Classification in Egyptian, Sumerian, and Nahuatl -- $tAll Creatures Great and Small ? The Ancient Egyptian View of the Animal World -- $tClassification Systems and Pharmacological Theory in Medieval Collections of Materia Medica: A Short History from the Antiquity to the End of the 12th Century -- $tClassification in Ancient Egyptian Medical Formulae and its Role in Re-Discovering Comprehensive and Specific Concepts of Drugs and Effects -- $tClassification between Grammar and Culture ? a Cross-Linguistic Perspective -- $tClassification and Naming of Living Objects ? a Biologist?s Perspective (Extended Abstract) -- $tTools, Agency and the Category of Living Things -- $tCategorizing Natural Objects: Some Issues Arising from Recent Work in Cognitive Anthropology and Ethnobiological Classification -- $tFrames as a Model for the Analysis and Description of Concepts, Conceptual Structures, Conceptual Change and Concept Hierarchies -- $tTracing Concepts ? Semantic Network Analysis as a Heuristic Device for Classification -- $tIndex -- $tList of Contributors 330 $aFrühes Wissen um Mensch und Natur weist häufig kulturelle Parallelen auf. Daraus ergibt sich die Unterscheidung zwischen universellen und spezifischen Konzepten. Universell meint dabei weniger etwas, das überall und stets vorhanden ist, als vielmehr etwas, das zeitlich und räumlich bei vergleichbaren Voraussetzungen unabhängig entstehen kann. Der Band greift Phänomene der Klassifizierung und Kategorisierung in alten und modernen Kulturen auf. Im Vordergrund steht eine Gesamtschau der kulturellen Praktiken, wie Individuen und soziale Gruppen sich ihre Welt aufteilen und welche kognitiven Systeme dabei gruppenübergreifend wirksam werden. Wie kann man Klassifizierungen und Kategorisierungen auf der Ebene von Schrift, Sprache, Abbild und Frames fassen? Gibt es Hierarchisierungen? Werden differierende Klassifizierungssysteme in verschiedenen sozialen Gruppierungen bzw. in unterschiedlichen Medien sichtbar? Altertumswissenschaftler, Anthropologen, Linguisten u.a. gewinnen durch eine synchron und diachron vergleichende Perspektive Methoden zur Rückgewinnung früher Konzepte von Mensch und Natur. 330 $aThe volume presents phenomena of classification and categorisation in ancient and modern cultures and provides an overview of how cultural practices and cognitive systems interact when individuals or larger groups conceptually organize their world. Scientists of antiquity studies, anthropologists, linguists etc. will find methods to reconstruct early concepts of men and nature from a synchronic and diachronic comparative perspective. 606 $aKnowledge, Theory of 606 $aInformation organization 606 $aCategories (Philosophy) 608 $aElectronic books. 615 0$aKnowledge, Theory of. 615 0$aInformation organization. 615 0$aCategories (Philosophy) 676 $a001.01/2 686 $aAK 22900$qBVB$2rvk 702 $aPommerening$b Tanja 702 $aBisang$b Walter 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910467824203321 996 $aClassification from antiquity to modern times$92453385 997 $aUNINA LEADER 03333nam 2200457z- 450 001 9910136797603321 005 20210212 035 $a(CKB)3710000000631146 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61176 035 $a(oapen)doab61176 035 $a(EXLCZ)993710000000631146 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTranscriptional Regulation in Cancers and Metabolic Diseases 210 $cFrontiers Media SA$d2015 215 $a1 online resource (98 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-712-3 330 $aThe transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression during the formation of malignant cells. Extensive work has been done on the critical TFs in various disease models. Despite the success of numerous TF-targeted therapies, there remain significant hurdles understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern TF action. This effort is now beginning to produce exciting new avenues of research. A clinically relevant topic for genetic change of TF is the mutant isoforms of p53, the most famous tumor suppressor. The p53 mutations either results in loss of function, or acting as dominant negative for wild-type protein, or 'gain of function' specifically promoting cancer survival. The gain of function is achieved by shifting p53 binding partner proteins, or changed genomic binding landscape leading to a cancer-promoting transcriptome. Another example of genetic change of TF causing malignancy is the AML-ETO fusion protein in the human t(8;21)-leukemia. The fusion protein is an active TF, and more interestingly, new studies link the disease causing role of AML-ETO to the unique transcriptome in the hematopoietic stem cells. Nuclear receptors (NR) are a group of ligand-dependent TFs governing the expression of genes involved in a broad range of reproductive, developmental and metabolic programs. Genetic changes and epigenetic modifications of NRs lead to cancers and metabolic diseases. Androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) are well studied NRs in prostate, breast and endometrial cancers. The development in sequencing technology and computational genomics enable us to investigate the transcription programs of these master TFs in an unprecedented level. This Research Topic aims to present the most up-to-date progress in the field of transcription regulation in cancers and metabolic diseases. 606 $aMedicine$2bicssc 610 $aCancer stem cell 610 $aCell Cycle 610 $aepigenetics 610 $aexosome 610 $amicroRNA 610 $anuclear receptor 610 $ap53 610 $ap63 610 $asenescence 610 $atran 615 7$aMedicine 700 $aCarol Prives$4auth$01296294 702 $aWen Zhou$4auth 906 $aBOOK 912 $a9910136797603321 996 $aTranscriptional Regulation in Cancers and Metabolic Diseases$93023968 997 $aUNINA