LEADER 00934nam0 22003251i 450 001 990007033780403321 005 20180427094425.0 035 $a000703378 035 $aFED01000703378 035 $a(Aleph)000703378FED01 035 $a000703378 100 $a20020121d1990----km-y0itay50------ba 101 2 $aita$ceth 102 $aBE 105 $ay-------001yy 200 1 $a<>libro del mistero$fGiyorgis di Sagla 210 $aLovanii$cE. Peeters$d1990 215 $a2 v.$d24 cm 225 1 $aCorpus scriptorum Christianorum Orientalium$iScriptores Aethiopici$v89$v90 454 1$12001$aMashafa Mestir$928060 676 $a340.5$v20$zita 700 0$aGiyorgis Di Sagla$0413155 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990007033780403321 952 $aIV Z OR 5 (89)$b15028$fFGBC 952 $aIV Z OR (90)$b15029$fFGBC 959 $aFGBC 996 $aMashafa Mestir$928060 997 $aUNINA LEADER 03205nam 2200469z- 450 001 9910136797203321 005 20210211 035 $a(CKB)3710000000631150 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54469 035 $a(oapen)doab54469 035 $a(EXLCZ)993710000000631150 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeural Circuitry of Behavioral Flexibility: Dopamine and Related Systems 210 $cFrontiers Media SA$d2016 215 $a1 online resource (165 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-795-6 330 $aDecades of research have identified a role for dopamine neurotransmission in prefrontal cortical function and flexible cognition. Abnormal dopamine neurotransmission underlies many cases of cognitive dysfunction. New techniques using optogenetics have allowed for ever more precise functional segregation of areas within the prefrontal cortex, which underlie separate cognitive functions. Learning theory predictions have provided a very useful framework for interpreting the neural activity of dopamine neurons, yet even dopamine neurons present a range of responses, from salience to prediction error signaling. The functions of areas like the Lateral Habenula have been recently described, and its role, presumed to be substantial, is largely unknown. Many other neural systems interact with the dopamine system, like cortical GABAergic interneurons, making it critical to understand those systems and their interactions with dopamine in order to fully appreciate dopamine's role in flexible behavior. Advances in human clinical research, like exome sequencing, are driving experimental hypotheses which will lead to fruitful new research directions, but how do (or should?) these clinical findings inform basic research? Following new information from these techniques, we may begin to develop a fresh understanding of human disease states which will inform novel treatment possibilities. However, we need an operational framework with which to interpret these new findings. Therefore, the purpose of this Research Topic is to integrate what we know of dopamine, the prefrontal cortex and flexible behavior into a clear framework, which will illuminate clear, testable directions for future research. 517 $aNeural Circuitry of Behavioral Flexibility 606 $aNeurosciences$2bicssc 610 $aanterior cingulate cortex (ACC) 610 $aAttentional set-shifting 610 $abasal forebrain 610 $abehavioral flexibility 610 $aDopamine 610 $aendocannabinoid system 610 $alateral habenula (LHb) 610 $aLocus coeruleus (LC) 610 $amedial prefrontal cortex (mPFC) 610 $amotivational salience 615 7$aNeurosciences 700 $aMatthew R. Roesch$4auth$01326343 702 $aGregory B. Bissonette$4auth 906 $aBOOK 912 $a9910136797203321 996 $aNeural Circuitry of Behavioral Flexibility: Dopamine and Related Systems$93037356 997 $aUNINA