LEADER 02147nam  2200421z- 450 
001 9910136797103321
005 20231214133628.0
035   $a(CKB)3710000000631151
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48746
035   $a(EXLCZ)993710000000631151
100   $a20202102d2016      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aGolgi Pathology in Neurodegenerative Diseases
210   $cFrontiers Media SA$d2016
215   $a1 electronic resource (119 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-757-3 
330   $aThe Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus (fragmentation and atrophy), which are collectively termed Golgi pathology, are now recognized as a constant feature of many neuro-degenerative diseases. However, the molecular mechanisms underlying these changes and their precise relevance to neurodegeneration have not yet been completely elucidated. This eBook contains 13 reviews that address the molecular mechanisms of Golgi pathology in Parkinson and Alzheimer diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophies, and discuss their potential relevance to the pathological loss of neuronal cell bodies, axons and synapses.
610   $aNeurodegenerative Diseases
610   $aIntracellular membrane traffic
610   $aAmyotrophic Lateral Sclerosis
610   $asignaling
610   $aGolgi fragmentation
610   $aMicrotubules
610   $aCell Death
610   $aTethers
610   $amolecular motors
610   $avesicles
700   $aCatherine Rabouille$4auth$01291856
702   $aGeorg Haase$4auth
906   $aBOOK
912   $a9910136797103321
996   $aGolgi Pathology in Neurodegenerative Diseases$93022005
997   $aUNINA