LEADER 03238nam  2200409z- 450 
001 9910136794003321
005 20231214132818.0
035   $a(CKB)3710000000631048
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54963
035   $a(EXLCZ)993710000000631048
100   $a20202102d2015      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aNutrition and prevention of Alzheimer's disease
210   $cFrontiers Media SA$d2015
215   $a1 electronic resource (76 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-719-0 
330   $aAltered metabolism is known to be associated with a higher incidence of Alzheimer´s disease (AD). Diabetes type 2, obesity, and metabolic syndrome are considered risk factors for the development of dementias, including AD. These metabolic diseases may have a genetic predisposition, but most of them are caused by environmental factors and life-style. Most research has focused on the effect of a high-fat diet (HFD) and sweetened beverages that induce obesity. Importantly, a HFD can also trigger oxidative stress, neuro-inflammation and cognitive decline. Less is known, however, about beneficial effects of diet on cognition, such as slowing the progression or preventing AD by ingesting whole fruits, vegetables, fish and oil. It is important to highlight the difference between vitamin/mineral supplements and whole food, as it appears that the former are clinically ineffective, while multiple ingredients in the latter act synergistically to improve cognition. As AD is a disease of slow progression, therapies should start several decades before clinical symptoms can be observed; one strategy can be the ingestion of healthy food in those subjects with one or more risk factors (genetic, environmental, life-style) already in their 40s, just when some brain metabolic disturbances start to develop. This dietary therapy can overcome the increased reactive oxygen species, protein deposition and synaptic failure, characteristic of AD. This research topic will cover a range of research articles, case studies, opinion and mini-reviews, all focused on describing the damaging effects of an industrial diet on cognition as well as on highlighting the beneficial effects of a healthy diet to prevent AD. We believe that we still have time to fight against the negative impact of our industrialized cultures, and adopt better eating habits, increase exercise and slow down our life style to prevent increasing dementia in the aging population. Also, all these topics has been a product of intensives investigations, with a great life hope, and we hope you all enjoy reading this e-book.
610   $aDiet
610   $abiomarkers
610   $aAging
610   $adiagnosis
610   $aCognition
610   $aMinerals
610   $aFunctional Food
610   $aVitamins
610   $aDementia
700   $aClaudia Perez-Cruz$4auth$01322467
702   $aSofia Diaz Cintra$4auth
906   $aBOOK
912   $a9910136794003321
996   $aNutrition and prevention of Alzheimer's disease$93035040
997   $aUNINA