LEADER 04379nam 2200661 450 001 9910136793003321 005 20230621141332.0 035 $a(CKB)3710000000631055 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54509 035 $a(EXLCZ)993710000000631055 100 $a20160411h20162016 fy| 0 101 0 $aeng 135 $aurc|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeuromodulation of executive circuits /$fedited by: M. Victoria Puig, Allan T. Gulledge, Evelyn K. Lambe and Guillermo Gonzalez-Burgos 210 $cFrontiers Media SA$d2016 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2016. 210 4$dİ2016 215 $a1 online resource (257 pages) $cillustrations; digital file(s) 225 1 $aFrontiers Research Topics 225 1 $aFrontiers in Neural Circuits 311 $a2-88919-707-7 320 $aIncludes bibliographical references. 330 3 $aHigh-order executive tasks involve the interplay between frontal cortex and other cortical and subcortical brain regions. In particular, the frontal cortex, striatum and thalamus interact via parallel fronto-striatal ?loops? that are crucial for the executive control of behavior. In all of these brain regions, neuromodulatory inputs (e.g. serotonergic, dopaminergic, cholinergic, adrenergic, and peptidergic afferents) regulate neuronal activity and synaptic transmission to optimize circuit performance for specific cognitive demands. Indeed, dysregulation of neuromodulatory input to fronto-striatal circuits is implicated in a number of neuropsychiatric disorders, such as schizophrenia, depression, and Parkinson's Disease. However, despite decades of intense investigation, how neuromodulators influence the activity of fronto-striatal circuits to generate the precise activity patterns required for sophisticated cognitive tasks remains unknown. In part, this reflects the complexity of the cellular microcircuits in these brain regions (i.e. heterogeneity of neuron subtypes and connectivity), cell-type specific expression patterns for the numerous receptor subtypes mediating neuromodulatory signals, and the potential interaction of multiple signaling cascades in individual neurons. The scope of this Topic includes, but is not limited to, studies aimed at understanding: 1) the actions of neuromodulators on neural activity in the frontal cortex and other cortical regions, the striatum, thalamus, and other regions involved in executive function; 2) neural and behavioral responses in laboratory animals to genetic, molecular, and pharmacological manipulation of neuromodulatory transmission in these regions; 3) the involvement of neuromodulatory systems in facilitating higher-order executive tasks in humans (e.g. pharmacology, fMRI, and EEG studies); and 4) animal models of neurological and psychiatric disorders involving abnormal neuromodulation of areas important for executive function. Studies that focus on executive circuits as well as just one brain level (e.g. cerebral cortex, striatum, or thalamus) are welcome. 410 0$aFrontiers research topics. 410 0$aFrontiers in neural circuits. 606 $aExecutive functions (Neuropsychology) 606 $aClinical neuropsychology 606 $aNeuropsychology$xResearch 606 $aNeurotransmitters$xPathophysiology 606 $aNeurotransmitters$xPhysiological effect 610 $aDopamine 610 $aSerotonin 610 $aThalamus 610 $anoradrenaline 610 $aAcetylcholine 610 $aBasal Ganglia 610 $aExecutive Function 610 $aPrefrontal Cortex 615 0$aExecutive functions (Neuropsychology) 615 0$aClinical neuropsychology. 615 0$aNeuropsychology$xResearch. 615 0$aNeurotransmitters$xPathophysiology. 615 0$aNeurotransmitters$xPhysiological effect. 676 $a612.8 700 $aEvelyn K. Lambe$4auth$01363991 702 $aPuig$b M. Victoria 702 $aGulledge$b Allan T. 702 $aLambe$b Evelyn K. 702 $aGonzalez-Burgos$b Guillermo 712 02$aFrontiers Research Foundation, 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136793003321 996 $aNeuromodulation of executive circuits$93385062 997 $aUNINA