LEADER 04303nam 2200565 450 001 9910136791803321 005 20230621135410.0 035 $a(CKB)3710000000631062 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40170 035 $a(EXLCZ)993710000000631062 100 $a20160411h20152015 fy| 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe adrenergic system in cardiovascular physiology and pathophysiology$b[electronic resource] /$fedited by: Giuseppe Rengo 205 $aSecond edition. 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2015 210 4$dİ2015 215 $a1 online resource (78 pages) $cillustrations; digital, PDF file(s) 225 1 $aFrontiers Research Topics 225 1 $aFrontiers in Physiology 311 $a2-88919-731-X 320 $aIncludes bibliographical references. 330 3 $aCardiovascular diseases pose an enormous clinical challenge, remaining the most common cause of death in the world. ?-adrenoceptors play an important role on cardiac, vascular and/or endothelial function at a cellular level with relevant applications in several cardiovascular diseases, such as heart failure and hypertension. G protein?coupled receptors (GPCRs), including ?-adrenergic receptors, constitute the most ubiquitous superfamily of plasma membrane receptors and represent the single most important type of therapeutic drug target. Sympathetic nervous system hyperactivity, which characterizes several cardiovascular diseases, such as heart failure and hypertension, as well as physiological ageing, has been proved to exert in the long-term detrimental effects in a wide range of cardiovascular diseases. Acutely, sympathetic hyperactivity represents the response to an insult to the myocardium, aiming to compensate for decreased cardiac output. This process involves the activation of beta-adrenergic receptors by catecholamine with consequent heart rate and cardiac contractility increase. However, long-term exposure of the heart to elevated norepinephrine and epinephrine levels, originating from sympathetic nerve endings and chromaffin cells of the adrenal gland, results in further progressive deterioration in cardiac structure and function. At the molecular level, sustained sympathetic nervous system hyperactivity is responsible for several alterations including altered beta-adrenergic receptor signaling and function (down-regulation/desensitization). Moreover, the detrimental effects of catecholamine affect also the function of different cell types including, but not limited to, endothelial cells, fibroblasts and smooth muscle cells. Thus, the success of beta-blocker therapy is due, at least in part, to the protection of the heart and the vasculature from the noxious effects of augmented catecholamine levels. The current research topic aims to support the progress towards understanding the role of sympathetic nervous system under physiological conditions, and the contribution of its hyperactivity in the pathogenesis and progression of cardiovascular diseases. The topic is open to original studies, descriptions of new methodologies, reviews and opinions. 410 0$aFrontiers research topics. 410 0$aFrontiers in physiology. 606 $aCardiovascular system$xDiseases 606 $aCardiovascular system$xDiseases$xPathogenesis 606 $aCardiovascular system$xDiseases$xPrevention$xResearch 610 $aGRK2 610 $aBeta-adrenoceptors 610 $aexercise training 610 $aHeart Failure 610 $aSympathetic Nervous System 610 $abeta-blockers 610 $afunctional recovery 615 0$aCardiovascular system$xDiseases. 615 0$aCardiovascular system$xDiseases$xPathogenesis. 615 0$aCardiovascular system$xDiseases$xPrevention$xResearch. 700 $aGiuseppe Rengo$4auth$01351517 702 $aRengo$b Giuseppe 712 02$aFrontiers Research Foundation, 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136791803321 996 $aThe adrenergic system in cardiovascular physiology and pathophysiology$93114716 997 $aUNINA LEADER 04385nam 22007092 450 001 9910827626303321 005 20240405100843.0 010 $a1-316-22296-9 010 $a1-316-22301-9 010 $a1-316-22306-X 010 $a1-316-22302-7 010 $a1-316-61284-8 010 $a1-316-22307-8 010 $a1-139-13555-4 010 $a1-316-22304-3 010 $a1-316-22305-1 010 $a1-316-22308-6 035 $a(CKB)3710000000270124 035 $a(EBL)1823614 035 $a(SSID)ssj0001368048 035 $a(PQKBManifestationID)12538104 035 $a(PQKBTitleCode)TC0001368048 035 $a(PQKBWorkID)11448468 035 $a(PQKB)11472314 035 $a(UkCbUP)CR9781139135559 035 $a(Au-PeEL)EBL1823614 035 $a(CaPaEBR)ebr10961457 035 $a(CaONFJC)MIL660641 035 $a(OCoLC)894170494 035 $a(MiAaPQ)EBC1823614 035 $a(PPN)261313282 035 $a(EXLCZ)993710000000270124 100 $a20110804d2015|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGlobal environmental constitutionalism /$fJames R. May and Erin Daly$b[electronic resource] 205 $a1st ed. 210 1$aCambridge :$cCambridge University Press,$d2015. 215 $a1 online resource (xi, 414 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a1-322-29360-0 311 $a1-107-02225-8 320 $aIncludes bibliographical references and index. 327 $aPart I. Evolution and existence of environmental constitutionalism -- The nature of environmental constitutionalism -- Textualizing environmental constitutionalism -- Part II. Vindication and practices in environmental constitutionalism -- Adjudicating environmental constitutionalism -- Enforcing environmental constitutionalism -- Identifying remedies and practices in environmental constitutionalism -- Part III. Emergence and future of environmental constitutionalism -- Water and environmental constitutionalism -- Subnational environmental constitutionalism -- Procedural environmental constitutionalism -- Emerging environmental constitutionalism -- Appendix A. Substantive environmental rights -- Appendix B. Individual environmental duties and responsibilities -- Appendix C. State environmental duties -- Appendix D. Environmental policy directives -- Appendix E. Sustainable development, future generations, and public trust -- Appendix F. Miscellaneous constitutional environmental provisions -- Appendix G. Right to water -- Appendix H. Representative subnational environmental constitutionalism in Brazil and the United States -- Appendix I. Procedural environmental rights : provisions regarding information, participation, and access to justice in environmental matters. 330 $aReflecting a global trend, scores of countries have affirmed that their citizens are entitled to healthy air, water and land, and that their constitution should guarantee certain environmental rights. This book examines the increasing recognition that the environment is a proper subject for protection in constitutional texts and for vindication by constitutional courts. This phenomenon, which the authors call environmental constitutionalism, represents the confluence of constitutional law, international law, human rights and environmental law. National apex and constitutional courts are exhibiting a growing interest in environmental rights, and as courts become more aware of what their peers are doing, this momentum is likely to increase. This book explains why such provisions came into being, how they are expressed, and the extent to which they have been, and might be, enforced judicially. It is a singular resource for evaluating the content of and hope for constitutional environmental rights. 606 $aEnvironmental law 606 $aConstitutional law 615 0$aEnvironmental law. 615 0$aConstitutional law. 676 $a344.04/6 686 $aLAW034000$2bisacsh 700 $aMay$b James R.$0282899 702 $aDaly$b Erin 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910827626303321 996 $aGlobal environmental constitutionalism$93925864 997 $aUNINA