LEADER 02755oam 2200517 450 001 9910136791603321 005 20230621140429.0 010 $a9782889197668 (ebook) 035 $a(CKB)3710000000631063 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44727 035 $a(EXLCZ)993710000000631063 100 $a20191103c2016uuuu -u- - 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDendritic spines $efrom shape to function /$fedited by Nicolas Heck and Ruth Benavides-Piccione 210 $cFrontiers Media SA$d2016 210 1$aFrance :$cFrontiers Media SA,$d2016 215 $a1 online resource (235 pages) $cillustrations 225 1 $aFrontiers Research Topics 320 $aIncludes bibliographical references. 330 $aOne fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dendrite reflects the levels of connectivity within the neuronal network. Furthermore, the relevance of studying dendritic spines is emphasized by the observation that their morphology changes with synaptic plasticity and is altered in many psychiatric disorders. The present Research Topic deals with some of the most recent findings concerning dendritic spine structure and function, showing that, in order to understand how brain neuronal activity operates, these two factors should be regarded as being intrinsically linked. 517 $aDendritic spines 606 $aDendrites 606 $aPyramidal cell 606 $aCerebral cortex 606 $aSynapses 610 $aSynaptic integration 610 $apyramidal cell 610 $aCerebral Cortex 610 $aDendrites 610 $aSynapses 615 0$aDendrites. 615 0$aPyramidal cell. 615 0$aCerebral cortex. 615 0$aSynapses. 676 $a612.8 700 $aNicolas Heck$4auth$01366915 702 $aHekc$b Nicholas 702 $aBenavides-Piccione$b Ruth 801 0$bUkMaJRU 912 $a9910136791603321 996 $aDendritic spines$93389439 997 $aUNINA