LEADER 04372oam 2200637 450 001 9910136791503321 005 20230621135338.0 010 $a9782889197323$b(ebook) 035 $a(CKB)3710000000631064 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56388 035 $a(EXLCZ)993710000000631064 100 $a20191103h20162016 fy| 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPlasticity of GABAergic synapses /$fedited by: Andrea Barberis and Alberto Bacci 210 $cFrontiers Media SA$d2016 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d[2016] 210 4$dİ2016 215 $a1 online resource (175 pages) $cillustrations (chiefly colour); digital file(s) 225 1 $aFrontiers Research Topics 300 $a"Published in: Frontiers in cellular neuroscience" -- front cover. 311 08$aPrint version: Plasticity of GABAergic synapses. [Lausanne, Switzerland] : Frontiers Media SA, 2016 2889197328 320 $aIncludes bibliographical references .. 330 $aLearning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses were assumed relatively invariant, to ensure stable and reliable control of the neuronal network. As a consequence, while considerable efforts were made to clarify the main mechanisms underlying plasticity at excitatory synapses, the study of the cellular/molecular mechanisms of inhibitory plasticity has received much less attention. Nevertheless, an increasing body of evidence has revealed that inhibitory synapses undergo several types of plasticity at both pre- and postsynaptic levels. Given the crucial role of inhibitory interneurons in shaping network activities, such as generation of oscillations, selection of cell assemblies and signal integration, modifications of the inhibitory synaptic strength represents an extraordinary source of versatility for the fine control of brain states. This versatility also results from the rich diversity of GABAergic neurons in several brain areas, the specific role played by each inhibitory neuron subtype within a given circuit, and the heterogeneity of the properties and modulation of GABAergic synapses formed by specific interneuron classes. The molecular mechanisms underlying the potentiation or depression of inhibitory synapses are now beginning to be unraveled. At the presynaptic level, retrograde synaptic signaling was demonstrated to modulate GABA release, whereas postsynaptic forms of plasticity involve changes in the number/gating properties of GABAA receptors and/or shifts of chloride gradients. In addition, recent research indicates that GABAergic tonic inhibition can also be plastic, adding a further level of complexity to the control of the excitatory/inhibitory balance in the brain. The present Topic will focus on plasticity of GABAergic synapses, with special emphasis on the molecular mechanisms of plasticity induction and/or expression. 410 0$aFrontiers research topics. 606 $aNeuroplasticity 606 $aNeural circuitry$xAdaptation 606 $aLearning$xPhysiological aspects 606 $aMemory$xPhysiological aspects 606 $aGABAergic Neurons 610 $astructural plasticity 610 $aInterneurons 610 $areceptor lateral diffusion 610 $ainhibitory post-synaptic density 610 $aGABAergic synapses 610 $agephyrin 610 $aGABAergic plasticity 610 $ainhibitory plasticity 610 $aGABAA receptors 610 $ainhibitory circuits 615 0$aNeuroplasticity. 615 0$aNeural circuitry$xAdaptation. 615 0$aLearning$xPhysiological aspects. 615 0$aMemory$xPhysiological aspects. 615 2$aGABAergic Neurons 700 $aAlberto Bacci$4auth$01367175 702 $aBarberis$b Andrea 702 $aBacci$b Alberto 801 0$bUkMaJRU 906 $aBOOK 912 $a9910136791503321 996 $aPlasticity of GABAergic synapses$93389894 997 $aUNINA