LEADER 05161nam 2200757 450 001 9910136459603321 005 20200520144314.0 010 $a3-527-68241-4 010 $a3-527-68238-4 010 $a3-527-68239-2 035 $a(CKB)3710000000616923 035 $a(EBL)4451995 035 $a(OCoLC)945612679 035 $a(SSID)ssj0001682976 035 $a(PQKBManifestationID)16508198 035 $a(PQKBTitleCode)TC0001682976 035 $a(PQKBWorkID)15037296 035 $a(PQKB)11729952 035 $a(MiAaPQ)EBC4451995 035 $a(Au-PeEL)EBL4451995 035 $a(CaPaEBR)ebr11174384 035 $a(CaONFJC)MIL909458 035 $a(PPN)194624633 035 $a(EXLCZ)993710000000616923 100 $a20160326h20162016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHost - pathogen interaction $emicrobial metabolism, pathogenicity and antiinfectives /$fedited by Gottfried Unden, Eckhard Thines, and Anja Schu?ffler 210 1$aWeinheim, Germany :$cWiley-VCH Verlag GmbH & Company KGaA,$d2016. 210 4$dİ2016 215 $a1 online resource (237 pages.) 225 1 $aDrug discovery in infectious diseases 300 $aDescription based upon print version of record. 311 $a3-527-33745-8 320 $aIncludes bibliographical references and index. 327 $aCover; Title Page; Copyright; Contents; Preface; Cover Legend; List of Contributors; Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction; Chapter 1 Metabolic Adaptation of Human Pathogenic Yersiniae; Introduction; Yersinia Life Cycles and Pathogenesis; Carbon Metabolism and Links to Yersinia Pathogenesis; Food Sources, Nutrient Sequestration, and Utilization; Metabolic Pathways of Yersinia Crucial for Virulence; Nutritional Virulence: Nutritional Adaptation Important for Pathogenesis; Coordinated Control of Carbon Metabolism and Virulence; Importance of Ions 327 $aImportance of the Csr SystemImportance of CCR and the cAMP-Crp Complex; Importance of Posttranscriptional Regulation Strategies; Conclusions; Acknowledgments; References; Chapter 2 Crosstalk between Metabolism and Virulence of Legionella pneumophila; Introduction; Key Metabolic Features of L. pneumophila; Serine and Glucose Metabolism of L. pneumophila under In Vitro Conditions; Metabolism of L. pneumophila under Intracellular Conditions; Metabolic Adaptation during the Life Cycle of Intracellular L. pneumophila; Metabolic Host Cell Responses Triggered by Intracellular L. pneumophila 327 $aConclusionReferences; Chapter 3 Metabolism of Intracellular Salmonella enterica; Introduction; S. enterica-A Metabolic Generalist; Metabolism of Glucose by S. enterica; Connection to the TCA Cycle by Oxidative Decarboxylation of Pyruvate; The Important Role of the TCA Cycle and Anaplerotic Reactions; Metabolism of Intracellular S. enterica; The Metabolism of S. enterica Compared to Other Important Intracellular and Gastrointestinal Pathogens; Salmonella Induce Networks of Tubular Structures-Access to Host-Derived Nutrients?; S. enterica Has a Bimodal Lifestyle in Epithelial Cells 327 $aSalmonella Metabolism Limits Possibilities for New AntimicrobialsConclusions; References; Chapter 4 The Human Microbiome in Health and Disease; Introduction; Methods for Characterizing the Microbiota; Diet and Geographical Factors; Functional Gastrointestinal Disorders; Manipulation of the Microbiota; Conclusions; Acknowledgments; References; Chapter 5 Mechanisms of Dysbiosis in the Inflamed Gut; Introduction; Dysbiosis during Inflammatory Diseases of the Gastrointestinal Tract; Nutrient Acquisition by Commensal Bacteria in the Normal Gut 327 $aNutritional Mechanisms for Dysbiosis in the Inflamed GutInflammation-Driven Bloom of Enteric Pathogens in the Gut Lumen; How Anaerobic Respiration Enhances Growth in the Inflamed Gut; Conclusions; References; Chapter 6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice; Introduction; Adhesion and Germination; Appressorium Formation; Penetration; Growth in Planta: The Biotrophic Growth Phase; Growth in Planta: Necrotrophic Growth Phase; Growth in Planta: Sporulation; Life Outside of the Rice Plant; Conclusion; References 327 $aPart Two New Inhibitors and Targets of Infectious Diseases 410 0$aDrug discovery in infectious diseases. 606 $aHost-parasite relationships 606 $aCommunicable diseases 606 $aInfection 606 $aPathogenic microorganisms 606 $aAnti-infective agents 615 0$aHost-parasite relationships. 615 0$aCommunicable diseases. 615 0$aInfection. 615 0$aPathogenic microorganisms. 615 0$aAnti-infective agents. 676 $a577.857 702 $aUnden$b Gottfried 702 $aThines$b Eckhard 702 $aSchu?ffler$b Anja 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910136459603321 996 $aHost - pathogen interaction$92221645 997 $aUNINA