LEADER 04401nam 2200541 450 001 9910136413703321 005 20230808191828.0 010 $a3-527-68338-0 010 $a1-5231-1519-X 010 $a3-527-68336-4 010 $a3-527-68337-2 035 $a(CKB)3710000000604591 035 $a(EBL)4455005 035 $a(MiAaPQ)EBC4455005 035 $a(Au-PeEL)EBL4455005 035 $a(CaPaEBR)ebr11176450 035 $a(CaONFJC)MIL898848 035 $a(OCoLC)945873904 035 $a(EXLCZ)993710000000604591 100 $a20160407h20162016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aBioreactors $edesign, operation and novel applications /$fedited by Carl-Fredrik Mandenius 210 1$aWeinheim, Germany :$cWiley-VCH Verlag GmbH & Company KGaA,$d[2016] 210 4$dİ2016 215 $a1 online resource (603 p.) 300 $aDescription based upon print version of record. 311 $a3-527-33768-7 320 $aIncludes bibliographical references and index. 327 $aTitle Page; Copyright; Table of Contents; Preface; List of Contributors; Chapter 1: Challenges for Bioreactor Design and Operation; 1.1 Introduction; 1.2 Biotechnology Milestones with Implications on Bioreactor Design; 1.3 General Features of Bioreactor Design; 1.4 Recent Trends in Designing and Operating Bioreactors; 1.5 The Systems Biology Approach; 1.6 Using Conceptual Design Methodology; 1.7 An Outlook on Challenges for Bioreactor Design and Operation; References; Chapter 2: Design and Operation of Microbioreactor Systems for Screening and Process Development; 2.1 Introduction 327 $a2.2 Key Engineering Parameters and Properties in Microbioreactor Design and Operation2.3 Design of Novel Stirred and Bubble Aerated Microbioreactors; 2.4 Robotics for Microbioreactors; 2.5 Fed-Batch and Continuous Operation of Microbioreactors; 2.6 Monitoring and Control of Microbioreactors; 2.7 Conclusion; References; Chapter 3: Bioreactors on a Chip; 3.1 Introduction; 3.2 Advantages of Microsystems; 3.3 Scaling Down the Bioreactor to the Microfluidic Format; 3.4 Microfabrication Methods for Bioreactors-On-A-Chip; 3.5 Fabrication Materials 327 $a3.6 Integrated Sensors for Key Bioreactor Parameters3.7 Model Organisms Applied to BRoCs; 3.8 Applications of Microfluidic Bioreactor Chip; 3.9 Scale Up; 3.10 Conclusion; References; Chapter 4: Scalable Manufacture for Cell Therapy Needs; 4.1 Introduction; 4.2 Requirements for Cell Therapy; 4.3 Stem Cell Types and Products; 4.4 Paradigms in Cell Therapy Manufacture; 4.5 Cell Therapy Manufacturing Platforms; 4.6 Microcarriers and Stirred-Tank Bioreactors; 4.7 Future Trends for Microcarrier Culture; 4.8 Preservation of Cell Therapy Products; 4.9 Conclusions; References 327 $aChapter 5: Artificial Liver Bioreactor Design5.1 Need for Innovative Liver Therapies; 5.2 Requirements to Liver Support Systems; 5.3 Bioreactor Technologies Used in Clinical Trials; 5.4 Optimization of Bioartificial Liver Bioreactor Designs; 5.5 Improvement of Cell Biology in Bioartificial Livers; 5.6 Bioreactors Enabling Cell Production for Transplantation; 5.7 Cell Sources for Bioartificial Liver Bioreactors; 5.8 Outlook; References; Chapter 6: Bioreactors for Expansion of Pluripotent Stem Cells and Their Differentiation to Cardiac Cells; 6.1 Introduction 327 $a6.2 Culture Technologies for Pluripotent Stem Cell Expansion6.3 3D Suspension Culture; 6.4 Autologous Versus Allogeneic Cell Therapies: Practical and Economic Considerations for hPSC Processing; 6.5 Upscaling hPSC Cardiomyogenic Differentiation in Bioreactors; 6.6 Conclusion; References; Chapter 7: Culturing Entrapped Stem Cells in Continuous Bioreactors; 7.1 Introduction; 7.2 Materials Used in Stem Cell Entrapment; 7.3 Synthetic Materials; 7.4 Natural Materials; 7.5 Manufacturing and Regulatory Constraints; 7.6 Mass Transfer in the Entrapment Material 327 $a7.7 Continuous Bioreactors for Entrapped Stem Cell Culture 606 $aBioreactors$xDesign and construction 615 0$aBioreactors$xDesign and construction. 702 $aMandenius$b Carl-Fredrik 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910136413703321 996 $aBioreactors$92242074 997 $aUNINA