LEADER 03554nam 2200445z- 450 001 9910136403503321 005 20210211 035 $a(CKB)3710000000612061 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52951 035 $a(oapen)doab52951 035 $a(EXLCZ)993710000000612061 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMechanisms underlying firing in healthy and sick human motoneurons 210 $cFrontiers Media SA$d2015 215 $a1 online resource (134 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-592-9 330 $aSince the latter half of the twentieth century an enormous amount of knowledge about mammalian motoneuron pools has been collected. This progress was enabled mostly by the development of the precise techniques of intracellular recordings in acute animal experiments, many of which were conducted under deep anaesthesia. Recently obtained evidence indicates that anaesthetics used at that times changed certain properties of the cell membrane, which might affect firing of the neuron. Experiments on normal humans gets around this problem, which lets one compare MN firing characteristics in humans and reduced preparations. Firing pattern of human motoneurons is obtained indirectly by recording from a few muscle fibres of a motor unit. Since there is one-to-one relationship between motor unit and motoneuron firing, the statistical analysis of motor unit firing is equivalent to the analysis of motoneuron firing. This analysis, based on the essential knowledge about motoneuron physiology, gained from the direct measurements in animal experiments and verified by computer simulations, allows one to draw conclusions about the physiological properties of human motoneurons. For obvious reasons, the deductions made on properties of human motoneuron from these analyses should be accepted with caution. On the other hand, human experiments provide the unique opportunity to study intact motoneurons during normal physiological behavior. Thus, combining information obtained from animal and human experiments, and computer simulations, gives insight into underexplored problems of motor control. This E-book contains a collection of articles with range of exciting findings on the physiology and pathology of human motoneurons. The collection covers such important issues concerning firing of healthy motoneurons as recruitment and rate coding as well as motoneuron excitability, discusses intrinsic motoneuron properties disclosed by studying double discharges, and provides information on broad spectrum of motoneuron pathology. It is our hope that this collection promotes further expansion of knowledge on human motoneurons. 606 $aNeurosciences$2bicssc 610 $aafterhyperpolarization and delayed depolarization 610 $aaxon and peripheral afferents 610 $aDouble and triple discharges 610 $aexcitability 610 $ahuman motoneuron discharge mechanisms 610 $amotoneuron pathology 610 $amotor unit 610 $aRecruitment and rate coding 615 7$aNeurosciences 700 $aAnnie Schmied$4auth$01331567 702 $aParveen N S Bawa$4auth 702 $aMaria Piotrkiewicz$4auth 906 $aBOOK 912 $a9910136403503321 996 $aMechanisms underlying firing in healthy and sick human motoneurons$93040439 997 $aUNINA