LEADER 02956oam 2200421z 450 001 9910136401403321 005 20241204164158.0 010 $a9782889195916 (eboook) 035 $a(CKB)3710000000612077 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/39892 035 $a(oapen)doab39892 035 $a(EXLCZ)993710000000612077 100 $a20191103c2015uuuu ku 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cn$2rdamedia 183 $anc$2rdacarrier 200 10$a30 years old $eO-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation /$fedited by Tony Lefebvre and Tarik Issad 210 $cFrontiers Media SA$d2015 210 1$aSwitzerland :$cFrontiers Media SA,$d2007-2015 215 $a1 online resource (113 pages) $cillustrations 225 1 $aFrontiers Research Topics 320 $aIncludes bibliographical references. 330 $aHundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart. 517 $a30 years old 606 $aCell signalling 606 $aMetabolism 615 0$aCell signalling 615 0$aMetabolism. 676 $a572/.567 700 $aTarik Issad$4auth$01304492 702 $aLefebvre$b Tony 702 $aIsaad$b Tarik 801 0$bUkMaJRU 912 $a9910136401403321 996 $a30 years old$93402604 997 $aUNINA