LEADER 04534nam 2200529 450 001 9910136287303321 005 20230807211349.0 035 $a(CKB)3710000000586886 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40883 035 $a(EXLCZ)993710000000586886 100 $a20160208c2015uuuu fy| 0 101 0 $aeng 135 $aurc|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAnimal model studies on viral infections$b[electronic resource] /$fTopic editors: Akio Adachi and Tomoyuki Miura 210 $cFrontiers Media SA$d2015 210 1$a[Place of publication not identified] :$cFrontiers Media SA,$d2015. 210 4$dİ2007-2015 215 $a1 online resource (173 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers research topics 225 1 $aFrontiers in microbiology 311 $a2-88919-456-6 320 $aIncludes bibliographical references. 327 $aAnimal model studies on viral infections --Animal models for human Herpesvirus 6 infection --Animal models for Ebola and Marburg virus infections --Hepatitis C virus infection and related liver disease: the quest for the best animal model --Can non-human primates serve as models for investigating Dengue disease pathogenesis? --A transgenic mouse model of human T cell Leukemia virus type-1 associated diseases --Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus --Macaques as model hosts for studies of HIV-1 infection --Macaque-tropic Human Immunodeficiency Virus type 1: breaking out of the host restriction factors --Genetic similarity of circulating and small intestinal virus at the end stage of acute pathogenic Simian-Human Immunodeficiency Virus infection --A novel but simple method for generation of human dendritic cells from unfractionated peripheral blood mononuclear cells within 2 days: its application for induction of HIV-1-reactive CD4? T cells in the hu-PBL SCID mice --Growth potentials of CCR5-Tropic/CXCR4-Tropic HIV-1mt clones in macaque cells --Sensitive detection of measles virus infection in the blood and tissues of humanized mouse by one-step quantitative RT-PCR --Quantification of viral infection dynamics in animal experiments --Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells --Increased infectivity in human cells and resistant to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail --Natural infection of murine novovirus in conventional and specific pathogen free laboratory mice --HPV18 E1???E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins. 330 3 $aUnderstanding viral replication and pathogenicity properties in infected individuals is a major mission of animal virology. Animal models are essential to analyze the in vivo viral characteristics and to develop countermeasures against viruses. To fight against a wide variety of viruses, basic studies with specific and/ or common approaches are required. This Research Topic collects articles that describe studies on numerous virus species at various stages toward animal experiments: (i) description/evaluation/ new challenges of animal model studies; (ii) experimental material/methods for animal model studies; (iii) observations for upcoming animal model studies. Numbers of DNA and RNA viruses such as HHV-6, HPV, Ebola virus, HCV, dengue virus, HTLV-1, HIV-1, SIV, and measles virus are covered by this special issue consisting of original research, methods, review, mini-review, and opinion articles. All readers would understand, we believe and hope, that animal model studies are critical for current virology as always. 410 0$aFrontiers in microbiology. 606 $aMicrobiology 606 $aVirus diseases$xPathogenesis 606 $aVirology$xResearch 610 $aviral replication 610 $aanimal models 610 $aviral infections 610 $aanti-viral strategies 610 $aviral pathogenicity 615 0$aMicrobiology. 615 0$aVirus diseases$xPathogenesis. 615 0$aVirology$xResearch. 700 $aTomoyuki Miura$4auth$01378080 702 $aAdachi$b Akio 702 $aMiura$b Tomoyuki 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136287303321 996 $aAnimal model studies on viral infections$93416010 997 $aUNINA