LEADER 04342oam 2200613 450 001 9910136287103321 005 20230803214058.0 035 $a(CKB)3710000000586887 035 $a(SSID)ssj0001666876 035 $a(PQKBManifestationID)16455794 035 $a(PQKBTitleCode)TC0001666876 035 $a(PQKBWorkID)15000978 035 $a(PQKB)10035946 035 $a(WaSeSS)IndRDA00056547 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43556 035 $a(EXLCZ)993710000000586887 100 $a20160829h20142014 uy 0 101 0 $aeng 135 $aurmn#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe coming of age of insulin-signalling in insects$b[electronic resource] /$ftopic editors Xanthe Vafopoulou and Colin G. Steel 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2014. 210 4$dİ2014 215 $a1 online resource (138 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers research topics 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a2-88919-314-4 320 $aIncludes bibliographical references. 330 $aThe new millennium has seen a major paradigm shift in insect endocrinology. Great advancements are being made which establish that nutrition and growth play a central role in diverse cellular and physiological phenomena during insect development and reproduction. Nutrition affects rates of growth and is mainly regulated by the function of the pathway of insulin/insulin-like growth factor signalling. This pathway is highly conserved across species and ultimately regulates rates of cell growth and proliferation in growing organs. Insulin and insulin-like peptides (ILPs) are some of the best studied hormones in the animal kingdom and all share a common structural motif and initiate a wide range of closely similar physiological processes in higher organisms. In insects, nutrition, via circulating sugar, promotes release of ILPs from brain neurosecretory cells into the haemolymph, which act on peripheral tissues and stimulate protein synthesis and cell growth. Therefore, insect ILPs are common mediators between nutrition and growth in insects and are functionally analogous to mammalian insulin. The 1980s and 1990s witnessed great progress in elucidation of the physiological and molecular mechanism of action of numerous insect hormones involved in regulation of growth, development, reproduction and metabolism. But the signals for the initiation or termination of controlled events remained largely unknown. ILPs were first identified from the silkmoth Bombyx mori and were named bombyxins, but related peptides were soon found in numerous species and their functions elucidated. The insulin signalling pathway is now recognized as a central factor in the timing of cell proliferation, growth, longevity, reproduction, and reproductive diapause, as well as social behaviour. Recent work has revealed that the insulin signalling pathway is closely integrated with that of various other hormones, including ecdysteroids, the juvenile hormones and neuropeptide(s) such a prothoracicotropic hormone. In addition, the pathway is also linked with both circadian (daily) and photoperiodic (seasonal) clocks potentially providing a basis for its timing function. This Research Topic aims to provide the only current collection of recent advances on insect ILPs. 606 $aPhysiology 606 $aAnimal Biochemistry$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $ainsulin-like proteins 610 $atimekeeping 610 $ainteractions of signaling pathways 610 $anutrition and metabolism 610 $aGrowth and Development 615 0$aPhysiology. 615 7$aAnimal Biochemistry 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 700 $aColin G.H. Steel$4auth$01376292 702 $aVafopoulou$b Xanthe 702 $aSteel$b Colin G. 801 0$bPQKB 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136287103321 996 $aThe coming of age of insulin-signalling in insects$93411894 997 $aUNINA