LEADER 04439nam 2200793 450 001 9910136282403321 005 20230621140353.0 035 $a(CKB)3710000000586905 035 $a(SSID)ssj0001683368 035 $a(PQKBManifestationID)16509480 035 $a(PQKBTitleCode)TC0001683368 035 $a(PQKBWorkID)15037880 035 $a(PQKB)11451535 035 $a(WaSeSS)IndRDA00056647 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54513 035 $a(EXLCZ)993710000000586905 100 $a20160829h20142014 uy 0 101 0 $aeng 135 $aur||#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeuronal and psychological underpinnings of pathological gambling /$ftopic editors: Bryan F. Singer, Patrick Anselme, Mike J. F. Robinson and Paul Vezina 210 $cFrontiers Media SA$d2014 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2014. 215 $a1 online resource (132 pages) $cillustrations; digital file(s) 225 1 $aFrontiers Research Topics 225 1 $aFrontiers in Behavioral Neuroscience 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a2-88919-320-9 320 $aIncludes bibliographical references. 330 3 $aAlthough pathological gambling is a prevalent disease, its neurobiological and psychological underpinnings are not well characterized. Various lines of research suggest aberrant dopaminergic function may lead to pathological gambling. For example, human imaging studies have revealed dopaminergic activation coinciding with the performance of gambling-related tasks. Furthermore, dopamine D2-type receptor deficiency facilitates gambling behaviors and dopamine receptor agonist treatments for Parkinson?s disease have been shown to increase patient vulnerability to gambling. Pathological gambling is often co-morbid with drug addictions, and exposure to drugs of abuse has been shown to enhance motivation to gamble. The activation of midbrain dopamine neurons, as well as their terminal projection fields, is involved with the development and maintenance of various addictions. Importantly, recent articles have demonstrated that repeated exposure to conditions of gambling-like uncertain reinforcement lead to enhanced drive to seek reward, potentially through increasing the incentive motivational value of conditioned cues. Signaling molecules other than dopamine may also influence reward-seeking behaviors in pathological gamblers. For example, stress-related alterations in glucocorticoid signaling may effect decision making and influence gambling behavior. Together, these findings suggest common pathways exist that mediate gambling, drug dependence, stress, and movement disorders, and that cross-reactivity between these ailments may potentiate disease symptomology. The goal of this Research Topic is to further our understanding of the neurobiological mechanisms underlying the development of pathological gambling. 410 0$aFrontiers research topics. 410 0$aFrontiers in behavioral neuroscience. 606 $aDopamine$xPathophysiology 606 $aDopamine$xPhysiological effect 606 $aCompulsive behavior$xPathophysiology 606 $aCompulsive gambling$xEtiology 606 $aNeuropsychology 606 $aAnimal Biochemistry$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $astress 610 $aGambling 610 $aDopamine 610 $aAddiction 610 $aventral striatum 610 $aReward 610 $aConditioning 610 $auncertainty 615 0$aDopamine$xPathophysiology. 615 0$aDopamine$xPhysiological effect. 615 0$aCompulsive behavior$xPathophysiology. 615 0$aCompulsive gambling$xEtiology. 615 0$aNeuropsychology. 615 7$aAnimal Biochemistry 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 700 $aPatrick Anselme$4auth$01364021 702 $aSinger$b Bryan F 702 $aAnselme$b Patrick 702 $aRobinson$b Mike J. F. 702 $aVezina$b Paul 801 0$bPQKB 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136282403321 996 $aNeuronal and psychological underpinnings of pathological gambling$93385189 997 $aUNINA