LEADER 05320nam 2200673 a 450 001 9910459131603321 005 20200520144314.0 010 $a0-12-415912-5 035 $a(CKB)2660000000011057 035 $a(EBL)1208925 035 $a(OCoLC)847952648 035 $a(SSID)ssj0000968740 035 $a(PQKBManifestationID)12406882 035 $a(PQKBTitleCode)TC0000968740 035 $a(PQKBWorkID)10984789 035 $a(PQKB)11260314 035 $a(MiAaPQ)EBC1208925 035 $a(PPN)176637524 035 $a(Au-PeEL)EBL1208925 035 $a(CaPaEBR)ebr10718194 035 $a(CaONFJC)MIL495477 035 $a(EXLCZ)992660000000011057 100 $a20130621d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAnimal models for the study of human disease$b[electronic resource] /$fedited by P. Michael Conn 205 $a1st ed. 210 $aLondon $cElsevier$d2013 215 $a1 online resource (1109 p.) 300 $aDescription based upon print version of record. 311 $a1-299-64227-6 311 $a0-12-415894-3 320 $aIncludes bibliographical references and index. 327 $aFront Cover; ANIMAL MODELS FOR THE STUDY OF HUMAN DISEASE; Copyright; Contents; Preface; List of Contributors; Part I -ETHICS, RESOURCES AND APPROACHES; Chapter 1 - Ethics in Biomedical Animal Research: The Key Role of the Investigator; NATURE AND SCOPE OF THE CHAPTER; THE SUBJECT MATTER OF ANIMAL RESEARCH ETHICS; ASPECTS OF ANIMAL USE AND CARE RELEVANT TO ANIMAL RESEARCH ETHICS; WHY INVESTIGATORS ARE UNIQUELY QUALIFIED TO ENGAGE IN ETHICAL ASSESSMENT OF ANIMAL RESEARCH; WHY INVESTIGATORS SHOULD COMMIT THEMSELVES TO ETHICAL CONDUCT OF ANIMAL RESEARCH 327 $aWHY INVESTIGATORS PLAY THE KEY ROLE IN ASSURING THE ETHICAL CONDUCT OF ANIMAL RESEARCH PROJECTS SOURCES OF SUPPORT AND GUIDANCE IN CONDUCTING ETHICAL RESEARCH; DEVELOPING USEFUL ETHICAL GUIDELINES; FUNDAMENTAL PRINCIPLES OF ANIMAL RESEARCH ETHICS; PRACTICAL ETHICAL GUIDELINES FOR INVESTIGATORS; SOME CURRENT DIFFICULT ISSUES IN ANIMAL RESEARCH ETHICS; GENERAL SUGGESTIONS FOR INVESTIGATORS; References; Chapter 2 - Access to Resources: A Model Organism Database for Humans; THE PROBLEM; THE LAMHDI SOLUTION; THE IDEAL SOLUTION; Acknowledgments; References 327 $aChapter 3 - The Advent of the Golden Era of Animal Alternatives INTRODUCTION; ANALYTICAL TOOLS FOR THE DETECTION OF FOOD-BORNE DISEASE; AN INVITRO SYSTEM TO ASSESS ADVERSE EFFECTS DURING DEVELOPMENT; DISEASES-IN-A-DISH; NONINVASIVE IMAGING AND RECORDING; CONCLUSIONS; References; Chapter 4 - Environmental Enrichment for Animals Used in Research; INTRODUCTION; APPLIED SCIENCE: ENRICHMENT AS A WELFARE TOOL; BASIC SCIENCE: ENRICHMENT AND ANIMAL MODELS; ENRICHMENT AND EXPERIMENTAL VARIABILITY; ENVIRONMENTAL ENRICHMENT REGULATIONS; IMPLEMENTING AN ENRICHMENT PLAN; CONCLUSIONS; Acknowledgments 327 $aReferences Part II -VISION; Chapter 5 - Animal Models of Age-Related Macular Degeneration; INTRODUCTION; COMPARATIVE RETINAL ANATOMY AND THE PATHOLOGY OF AMD; THE GENETICS OF AMD; INFLAMMATION IN AMD; HTRA1 AND LOC387715/ARMS2 IN AMD; OXIDATIVE DAMAGE AND AMD; LIPID METABOLISM AND AMD; SPONTANEOUSLY OCCURRING PRIMATE MODELS OF AMD; MODELING CHOROIDAL NEOVASCULARIZATION IN ADVANCED AMD; CONCLUSION; References; Chapter 6 - N-Methyl-N-Nitrosourea Animal Models for Retinitis Pigmentosa; INTRODUCTION; TIME-COURSE PROGRESSION OF MNU-INDUCED RETINAL DEGENERATION 327 $aRETINAL DEGENERATION CAUSED BY MNU IN VARIOUS ANIMAL SPECIESAGE-RELATED PHOTORECEPTOR CELL DAMAGE AND SENSITIVITY TO MNU; PHOTORECEPTOR CELL DEATH, CELL DEBRIS REMOVAL, AND RPE CELL MIGRATION; MOLECULAR MECHANISMS IN PHOTORECEPTOR CELL DEATH CAUSED BY MNU; THERAPEUTIC TRIALS AGAINST MNU-INDUCED PHOTORECEPTOR APOPTOSIS; CONCLUDING REMARKS; Acknowledgments; References; Part III -CARDIAC AND CARDIOVASCULAR; Chapter 7 - Animal Models of Myocardial Disease; INTRODUCTION; THE SPECTRUM OF CARDIOVASCULAR DISEASE; CHOICE OF ANIMAL SYSTEM; EXPERIMENTAL DESIGN; ISCHEMIC HEART DISEASE 327 $aSYSTOLIC HEART FAILURE 330 $aAnimal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine. The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer 606 $aDiseases$xAnimal models 606 $aLaboratory animals 606 $aPathology, Experimental 608 $aElectronic books. 615 0$aDiseases$xAnimal models. 615 0$aLaboratory animals. 615 0$aPathology, Experimental. 676 $a616.0273 701 $aConn$b P. 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