LEADER 03129oam 2200553I 450 001 9910136129103321 005 20230810001147.0 010 $a1-315-45405-X 010 $a1-315-45404-1 010 $a1-315-45403-3 024 7 $a10.4324/9781315454054 035 $a(CKB)3710000000912460 035 $a(MiAaPQ)EBC4717809 035 $a(OCoLC)960902227 035 $a(BIP)56988484 035 $a(BIP)55357494 035 $a(EXLCZ)993710000000912460 100 $a20180706e20171980 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aAddiction and brain damage /$fedited by derek Richter 210 1$aAbingdon, Oxon :$cRoutledge,$d2017. 215 $a1 online resource (308 pages) $cillustrations 225 0 $aRoutledge Library Editions: Addictions ;$vVolume 3 300 $aFirst published in 1980 by Croom Helm Ltd. 311 08$a1-138-21088-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $apt. 1. Biochemical and physiological mechanisms -- pt. 2. Clinical investigations. 330 $aOriginally published in 1980, recent research had produced new insights into how, at the biochemical level, alcohol and other drugs of abuse can impair metabolic and neuropsychiatric functions. Epidemiological studies were also demonstrating that even moderate drinking or drug abuse can produce significant brain damage. This book draws together the latest biochemical, physiological and clinical research on these topics at the time. The initial chapters discuss how alcohol can interfere with various functions: the adaptability of metabolic processes as governed by the ability of the liver to synthesise new enzymes, cell membrane transport, nervous transmission and the transport of nutrients into the brain. It is suggested that opiates, and possibly alcohol, may affect the endorphin system by blocking the uptake of specific amino acids. The second half of the book reports clinical investigations using biochemical studies, psychological tests, EEG investigations and Computerised Axial Tomography (CAT) scanning. It gives the first report of a long-term study by Lishman and co-workers using an improved tomography technique to assess brain damage in alcoholics. These studies give convincing evidence that heavy drinking, even at socially-acceptable levels, can cause serious brain damage in vulnerable people. 606 $aAlcohol$xPhysiological effect$vCongresses 606 $aPsychotropic drugs$xPhysiological effect$vCongresses 606 $aBrain damage$xEtiology$vCongresses 606 $aNeuropharmacology$vCongresses 615 0$aAlcohol$xPhysiological effect 615 0$aPsychotropic drugs$xPhysiological effect 615 0$aBrain damage$xEtiology 615 0$aNeuropharmacology 676 $a616.86/3 701 $aRichter$b derek$097914 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910136129103321 996 $aAddiction and brain damage$92201232 997 $aUNINA