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010   $a3-319-38882-7
024 7 $a10.1007/978-3-319-38882-3
035   $a(CKB)3710000000909073
035   $a(DE-He213)978-3-319-38882-3
035   $a(MiAaPQ)EBC4718756
035   $a(PPN)196325315
035   $a(EXLCZ)993710000000909073
100   $a20161017d2016      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 14$aThe Functional Nucleus /$fedited by David P. Bazett-Jones, Graham Dellaire
205   $a1st ed. 2016.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016.
215   $a1 online resource (VI, 513 p. 56 illus., 48 illus. in color.) 
311   $a3-319-38880-0 
327   $aPart I - Nuclear Periphery -- 1.Laminopathies/Howard Worman -- Part II Nuclear Bodies -- 2.Nucleolus/Marie-Line Dubois and François-Michel Boisvert -- 3.Speckles/splicing and disease/Michael Ladomery and Sebastian Oltean -- 4.PML, cancer and stem cells/Julia P. Hofmann and Paolo Salomoni -- Part III Chromosomes -- 5.Chromosome territories/Karen J. Meaburn, Bharat Burman and Tom Misteli -- 6.Telomeres and Chromosome Instability/Tsz Wai Chu and Chantal Autexier -- PART IV Nuclear Domains and Development -- 7.Polycomb bodies/Vincenzo Pirrotta -- 8.Ikaros domains/Karen E. Brown -- PART V Nuclear Domains and Cell Stress -- 9.Senescence/SAHFs/Tamir Chandra -- 10.DNA repair foci as facultative nuclear domains/Michael J. Hendzel and Hilmar Strickfaden -- 11.DNA damage and the nucleus/Jordan Pinder, Anastazja Grabarz, Evi Soutoglou and Graham Dellaire -- 12.Inflammation and the nucleus/Sona Hubackova , Simona Moravcova and Zdenek Hodny -- 13.Viral infection and the nucleus/Lori Frappier -- PART VI Macromolecular dynamics within the nucleus -- 14.Actin filaments/motors/Guillaume Huet and Maria K. Vartiainen -- 15.Molecular diffusion/Alexander Gansen and Jörg Langowski -- PART VII Chromatin transactions and epigenetics -- 16.Fibres/interactions/Christopher J.F. Cameron, James Fraser, Mathieu Blanchette, and Josée Dostie -- 17.DNA replication Sebastian Müller, Dan Filipescu and Geneviève Almouzni -- 18.Development and Epigenetics Nuphar Salts and Eran Meshorer -- 19.Epigenetics and disease/Sanaa Choufani and Rosanna Weksberg -- PART VIII Transcription and RNA metabolism -- 20.Transcription factories/Christopher Eskiw and Jenifer Mitchell -- 21.RNA transport Jonathan Sheinberger and Yaron Shav-Tal. .
330   $aThis book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
606   $aNucleic acids
606   $aCell biology
606   $aCytogenetics
606   $aNucleic Acid Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14011
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aCytogenetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12040
615  0$aNucleic acids.
615  0$aCell biology.
615  0$aCytogenetics.
615 14$aNucleic Acid Chemistry.
615 24$aCell Biology.
615 24$aCytogenetics.
676   $a572.84
702   $aBazett-Jones$b David P$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aDellaire$b Graham$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910136022003321
996   $aThe Functional Nucleus$92524202
997   $aUNINA