LEADER 01986nam 2200421 450 001 9910135389103321 005 20210405205239.0 035 $a(CKB)3810000000000276 035 $a(WaSeSS)IndRDA00058085 035 $a(EXLCZ)993810000000000276 100 $a20160623d1994 || | 101 0 $apor 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSau?de e povos indi?genas /$forganizado por Ricardo V. Santos & Carlos E. A. Coimbra Jr 210 1$aRio de Janeiro, Brazil :$cEditora FIOCRUZ,$d1994. 215 $a1 online resource (251 pages) 311 $a85-85676-05-1 311 $a85-7541-277-9 330 1 $a"Innovative collection of 10 articles by anthropologists and medical specialists with experience among South American indigenous peoples, principally in Brazil. Overall objective of volume is to integrate bioecological and sociocultural factors in the understanding of health and sickness in indigenous societies. Articles are thematically organized in three parts: 1) studies of pre-history and contact history, 2) ethnomedicine, and 3) impact of socioeconomic processes on health/sickness profiles"--Handbook of Latin American Studies, v. 57.$uhttp://www.loc.gov/hlas/ 606 $aIndians of South America$xMedicine 606 $aIndians of South America$xHealth and hygiene 606 $aIndians of South America$xSocial conditions 606 $aTraditional medicine$zSouth America 615 0$aIndians of South America$xMedicine. 615 0$aIndians of South America$xHealth and hygiene. 615 0$aIndians of South America$xSocial conditions. 615 0$aTraditional medicine 702 $aSantos$b Ricardo Ventura$f1964- 702 $aCoimbra Junior$b Carlos Everaldo Alvares$f1959- 801 0$bWaSeSS 801 1$bWaSeSS 906 $aBOOK 912 $a9910135389103321 996 $aSau?de e povos indi?genas$92171117 997 $aUNINA LEADER 03638nam 2200733Ia 450 001 9910806236703321 005 20200520144314.0 010 $a9786612782893 010 $a9781118097779 010 $a1118097777 010 $a9781282782891 010 $a1282782894 010 $a9780470890387 010 $a047089038X 010 $a9780470890370 010 $a0470890371 035 $a(CKB)2670000000047173 035 $a(EBL)589068 035 $a(OCoLC)669165475 035 $a(SSID)ssj0000433695 035 $a(PQKBManifestationID)11279317 035 $a(PQKBTitleCode)TC0000433695 035 $a(PQKBWorkID)10395016 035 $a(PQKB)11142716 035 $a(MiAaPQ)EBC589068 035 $a(Au-PeEL)EBL589068 035 $a(CaPaEBR)ebr10419055 035 $a(CaONFJC)MIL278289 035 $a(OCoLC)612188534 035 $a(FINmELB)ELB179633 035 $a(Perlego)1011403 035 $a(EXLCZ)992670000000047173 100 $a20100428d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiotransformation and metabolite elucidation of xenobiotics /$fedited by Ala F. Nassar 205 $a1st ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons$d2010 215 $a1 online resource (342 p.) 300 $aDescription based upon print version of record. 311 08$a9780470504789 311 08$a0470504781 320 $aIncludes bibliographical references and index. 327 $aBIOTRANSFORMATION AND METABOLITE ELUCIDATION OF XENOBIOTICS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: HUMAN BIOTRANSFORMATION; CHAPTER 2: ANALYTICAL TOOLS AND APPROACHES FOR METABOLITE IDENTIFICATION IN DRUG METABOLISM; CHAPTER 3: TOOLS OF CHOICE FOR ACCELERATING METABOLITE IDENTIFICATION: MASS SPECTROMETRY TECHNOLOGY DRIVES METABOLITE IDENTIFICATION STUDIES FORWARD; CHAPTER 4: IMPROVING DRUG DESIGN: CONSIDERATIONS FOR THE STRUCTURAL MODIFICATION PROCESS 327 $aCHAPTER 5: CASE STUDY: THE UNANTICIPATED LOSS OF N2 FROM NOVEL DNA ALKYLATING AGENT LAROMUSTINE BY COLLISION-INDUCED DISSOCIATION: NOVEL REARRANGEMENTSCHAPTER 6: CASE STUDY: IDENTIFICATION OF IN VITRO METABOLITE/DECOMPOSITION PRODUCTS OF THE NOVEL DNA ALKYLATING AGENT LAROMUSTINE; CHAPTER 7: STRATEGIES FOR THE DETECTION OF REACTIVE INTERMEDIATES IN DRUG DISCOVERY AND DEVELOPMENT; CHAPTER 8: SAFETY TESTING OF DRUG METABOLITES: MIST GUIDANCE IMPACT ON THE PRACTICE OF INDUSTRIAL DRUG METABOLISM; INDEX 330 $aThe goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tool 606 $aXenobiotics$xMetabolism 606 $aMetabolites$vIdentification 606 $aBiotransformation (Metabolism) 615 0$aXenobiotics$xMetabolism. 615 0$aMetabolites 615 0$aBiotransformation (Metabolism) 676 $a615.9 701 $aNassar$b Ala F$01639399 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910806236703321 996 $aBiotransformation and metabolite elucidation of xenobiotics$93982347 997 $aUNINA