LEADER 04083nam 2200469 450 001 9910134853003321 005 20221215203045.0 010 $a3-527-69493-5 010 $a3-527-69491-9 010 $a3-527-69490-0 035 $a(CKB)4330000000010666 035 $a(EBL)4688953 035 $a(MiAaPQ)EBC4688953 035 $a(EXLCZ)994330000000010666 100 $a20161010h20162016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aMetallomics $eanalytical techniques and speciation methods /$fedited by Bernhard Michalke 210 1$aWeinhem, Germany :$cWiley-VCH,$d[2016] 210 4$dİ2016 215 $a1 online resource (499 p.) 300 $aIncludes index. 311 $a3-527-33969-8 327 $aCover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Analytical Methods and Strategies in Metallomics; Chapter 1 The Position of Metallomics Within Other Omics Fields; 1.1 Introduction; 1.2 Metallome and Metallomics in Relation to Other ""-Ome"" and ""-Omics"" Fields; 1.2.1 Genomics; 1.2.2 Transcriptomics; 1.2.3 Proteomics; 1.2.4 Metabolomics; 1.2.5 Metallomics; 1.3 Is Metallomics Feasible as a Global Study of the Metallome; 1.4 Approaching the Metallome: Study of Metallome Subgroups; 1.5 Analytical Strategies in Metallomics; 1.5.1 Element Mass Spectrometry (ICP-MS) 327 $a1.5.2 Coupling Techniques1.5.3 Elemental Imaging Techniques; 1.5.4 Bioinformatic Approaches; 1.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals; 1.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup; 1.8 Concluding Remarks; References; Chapter 2 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques; 2.1 Introduction; 2.2 Analytical Techniques for Metallomics; 2.2.1 Overview about Available Separation Techniques; 2.3 Ionization Principles and Mass Spectrometric Detectors for Speciation 327 $a2.3.1 Element-Specific Detection with ICP-Based Techniques2.3.2 Electrospray Ionization-Mass Spectrometry (ESI-MS); 2.3.3 Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Techniques (MALDI-MS); 2.4 Overview about Coupling Techniques; 2.4.1 LC Couplings; 2.4.2 Coupling of CE and ICP-MS; 2.4.3 Laser Ablation (LA); 2.4.4 Gas Chromatography (GC); 2.5 Final Remarks and Outlook; References; Chapter 3 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis; 3.1 Introduction 327 $a3.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation3.2.1 Quality Assurance in Species Quantitation; 3.2.2 Quality Assurance in Species Identification; 3.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species; 3.3.1 IDMS and Speciation Analysis; 3.3.2 Quantitative Se Speciation in Food/Supplements by Species-Specific IDMS: Production of ""Speciated"" Reference Materials 327 $a3.3.3 Species-Specific Double IDMS Quantification of Plasma Selenoproteins: Advantages and Limitations in Comparison with the Species-Unspecific IDMS Approach3.3.4 Application of Species-Specific Double Spike IDMS to Account for Redox Exchange between Cr(III) and Cr(VI) Species: Practical Considerations for Quality Assurance; References; Chapter 4 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF; 4.1 Introduction; 4.2 Bioimaging by LA-ICP-MS; 4.2.1 Principle; 4.2.2 Elemental Bioimaging by LA-ICP-MS; 4.2.3 Quantitative Bioimaging by LA-ICP-MS 327 $a4.2.4 Proteomic Bioimaging by LA-ICP-MS 606 $aMetals$xPhysiological effect 615 0$aMetals$xPhysiological effect. 676 $a338.4779102854678 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910134853003321 996 $aMetallomics$91960579 997 $aUNINA