LEADER 05578nam 2200733Ia 450 001 9910133840103321 005 20200520144314.0 010 $a3-527-64000-2 010 $a1-283-86990-X 010 $a3-527-64001-0 010 $a3-527-63999-3 035 $a(CKB)3340000000000196 035 $a(EBL)843677 035 $a(OCoLC)797919435 035 $a(SSID)ssj0000622277 035 $a(PQKBManifestationID)11392464 035 $a(PQKBTitleCode)TC0000622277 035 $a(PQKBWorkID)10637770 035 $a(PQKB)10335196 035 $a(MiAaPQ)EBC843677 035 $a(Au-PeEL)EBL843677 035 $a(CaPaEBR)ebr10577567 035 $a(CaONFJC)MIL418240 035 $a(PPN)194594017 035 $a(EXLCZ)993340000000000196 100 $a20110806d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGenome organization and function in the cell nucleus$b[electronic resource] /$fedited by Karsten Rippe 210 $aHeidelberg, Germany $cWiley-VCH$dc2012 215 $a1 online resource (596 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32698-7 320 $aIncludes bibliographical references and index. 327 $aGenome Organization and Function in the Cell Nucleus; Contents; Preface; List of Contributors; 1: Deciphering DNA Sequence Information; 1.1: Introduction; 1.2: Genes and Transcribed Regions; 1.2.1: Open Reading Frames; 1.2.2: Mapping Transcriptional Start Sites; 1.2.3: Mapping Untranslated Regions on mRNA; 1.3: Non-Coding Genomic Elements; 1.3.1: Pseudogenes; 1.3.2: Repeats; 1.3.3: Structural Variants; 1.3.4: Methods for SV Detection; 1.3.5: Transposons and Retrotransposons; 1.4: Regulatory Information; 1.4.1: Classes of Regulatory Elements; 1.4.2: Transcription Factor Binding Motifs 327 $a1.4.3: Allele-Specific Expression1.5: Individual Genetic Polymorphisms and Their Effect on Gene Expression; 1.6: Conclusion; 2: DNA Methylation; 2.1: Introduction; 2.1.1: Discovery of 5-Methylcytosine in DNA; 2.1.2: Epigenetic Control of Gene Expression; 2.2: Eukaryotic DNA Methyltransferases; 2.2.1: Dnmt1; 2.2.2: The Dnmt3 Family; 2.2.3: Cooperative Function of Dnmts; 2.3: Distribution of 5-Methylcytosine in the Mammalian Genome; 2.3.1: Spatial Distribution of 5-Methylcytosine; 2.3.2: CpG Islands and Promoter Regulation; 2.3.3: Repetitive DNA Sequences 327 $a2.3.4: Temporal Distribution of 5-Methylcytosine2.4: Control of Gene Expression by DNA Methylation; 2.4.1: Loss of Transcription Factor Binding; 2.4.2: Methyl-CpG Binding Proteins; 2.4.3: Interconnection of DNA Methylation with Other Epigenetic Pathways; 2.4.4: DNA Methylation, Higher Order Chromatin Structure, and Nuclear Architecture; 2.5: DNA Demethylation; 3: Nucleosomes as Control Elements for Accessing the Genome; 3.1: Introduction and Basic Terminology; 3.2: Nucleosomes are the Building Blocks of Chromatin; 3.2.1: Histones; 3.2.2: Protein DNA Interactions in the Nucleosome 327 $a3.2.3: The Structure of Nucleosomal DNA3.3: Nucleosomes Are Dynamic Macromolecular Assemblies; 3.3.1: Mechanisms to Promote Histone Exchange In Vivo; 3.3.2: In Vitro Determination of Nucleosome Stability; 3.4: Histone Variants and Their Effect on Nucleosome Structure and Dynamics; 3.4.1: Variant Nucleosome Structures; 3.5: Histone Modifications in Nucleosome and Chromatin Structure; 3.6: DNA Sequence and Nucleosome Positioning; 3.6.1: Mechanisms for Nucleosome Exclusion; 3.6.2: Features that Promote Nucleosome Formation; 3.7: Histone Chaperones and Chromatin Dynamics; 3.7.1: Transcription 327 $a3.7.2: DNA Replication3.7.3: DNA Repair; 3.7.4: Mechanism of Chaperone-Mediated Nucleosome Assembly and Disassembly; 3.8: Outlook and Concluding Remarks; 4: Histone Modifications and Their Role as Epigenetic Marks; 4.1: The Complexity of Histone Modifications; 4.2: Regulating Histone Modifications in Chromatin; 4.3: The ""Histone Code"" Hypothesis; 4.3.1: Defining Histone ""Marks."" Why Is Histone Modification so Complex?; 4.3.2: Recognizing Histone Modifications: ""Reader"" Domains; 4.4: Exploiting the Complexity of the Histone Code: ""Crosstalk"" Between Different Modifications 327 $a4.4.1: Histone ""Crosstalk"": Increased Code Complexity and Signal Integration 330 $aBy way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gainedknowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair,recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions andnon-coding RNAs, chromatin structure, ep 606 $aMammals$xGenetics 606 $aGenomes 606 $aMolecular genetics 608 $aAufsatzsammlung. 608 $aAufsatzsammlung.$2gnd 615 0$aMammals$xGenetics. 615 0$aGenomes. 615 0$aMolecular genetics. 676 $a572.8619 686 $aWE 4000$2rvk 686 $a570$2sdnb 686 $aQU 350$2sdnb 701 $aRippe$b Karsten$0950107 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910133840103321 996 $aGenome organization and function in the cell nucleus$92147957 997 $aUNINA