LEADER 04917nam 2200625Ia 450 001 9910133642203321 005 20210604083343.0 010 $a3-527-63312-X 010 $a1-283-37048-4 010 $a9786613370488 010 $a3-527-63311-1 010 $a3-527-63310-3 035 $a(CKB)3400000000000398 035 $a(EBL)700915 035 $a(OCoLC)781613528 035 $a(SSID)ssj0000482171 035 $a(PQKBManifestationID)11288720 035 $a(PQKBTitleCode)TC0000482171 035 $a(PQKBWorkID)10484818 035 $a(PQKB)11107390 035 $a(MiAaPQ)EBC700915 035 $a(EXLCZ)993400000000000398 100 $a20101126d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBioinorganic medicinal chemistry$b[electronic resource] /$fedited by Enzo Alessio 210 $aWeinheim, Germany $cbWiley-VCH$dc2011 215 $a1 online resource (442 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32631-6 320 $aIncludes bibliographical references and index. 327 $aBioinorganic Medicinal Chemistry; Contents; List of Contributors; 1: Medicinal Inorganic Chemistry: State of the Art, New Trends, and a Vision of the Future: Nicola J. Farrer and Peter J. Sadler; 1.1: Introduction; 1.1.1: Metals in the Body: Essential Elements and Diseases of Metabolism; 1.1.2: Metals as Therapeutic Agents; 1.2: Antimicrobial Agents; 1.3: Antiviral Agents; 1.4: Systemic and Metabolic Diseases Including Inflammation; 1.4.1: Diabetes and Obesity; 1.4.2: Metal Homeostasis and Related Diseases; 1.5: Metal Chelating Agents; 1.6: Antiarthritic Drugs and Inflammation 327 $a1.7: Bipolar Disorder1.8: Anticancer Agents; 1.8.1: PtII Cytotoxic Agents; 1.8.2: PtIV Prodrugs; 1.8.3: Photoactivatable PtIV Complexes; 1.8.4: Ruthenium; 1.8.4.1: Interaction with Plasma Proteins; 1.8.4.2: Ruthenium Arenes; 1.8.5: Osmium; 1.8.6: Titanium; 1.8.7: Gold; 1.8.8: Tin; 1.8.9: Gallium; 1.8.10: Arsenic; 1.8.11: Copper; 1.8.12: Zinc; 1.8.13: Bismuth; 1.8.14: Molybdenum; 1.8.15: Photosensitizers: Porphyrins; 1.9: Small Molecule Delivery and Control; 1.9.1: Nitric Oxide (NO); 1.9.2: Carbon Monoxide (CO); 1.10: Diagnostic Agents; 1.11: Veterinary Medicinal Inorganic Chemistry 327 $a1.12: Conclusions and Vision2: Targeting Strategies for Metal-Based Therapeutics: Julia F. Norman and Trevor W. Hambley; 2.1: Introduction; 2.2: Physiological Targeting; 2.2.1: Antitumor Drugs Targeting Tumor Hypoxia; 2.2.2: Antitumor Drugs Targeting Vascular Structure; 2.2.3: Antitumor Drugs Targeting Tumor pH; 2.2.4: Light Activated Prodrugs; 2.3: Molecular Targeting; 2.3.1: Protein and Peptide Targeting; 2.3.1.1: Protein Receptor Binding; 2.3.2: Peptide Tethering; 2.3.2.1: Directing Effects; 2.3.3: Selective Activation; 2.3.4: DNA Targeting; 2.3.4.1: Duplex DNA Sequence Selectivity 327 $a2.3.4.2: Telomeric Targeting2.4: Immunological Targeting; 2.4.1: Antigen Targeting; 2.4.2: Antibody Tethering; 2.5: Concluding Remarks; 3: Current Status and Mechanism of Action of Platinum-Based Anticancer Drugs: Shanta Dhar and Stephen J. Lippard; 3.1: Introduction; 3.1.1: Platinum Chemotherapy and Cancer; 3.1.2: Palette of Current Platinum Chemotherapeutic Drugs; 3.1.3: Early History of Cisplatin and Approved Platinum Drugs for the Clinic; 3.2: Mechanism of Action of Cisplatin; 3.2.1: Cisplatin Accumulation; 3.2.2: Cisplatin Activation; 3.2.2.1: Binding to DNA Targets 327 $a3.2.2.2: Binding to Non-DNA Targets3.2.3: Cellular Processing of Platinum-DNA Adducts; 3.2.3.1: Cytotoxicity Associated with High Mobility Group (HMG) Proteins; 3.2.3.2: Cytotoxicity Associated with Non-HMG Proteins; 3.3: Limitations of Current Platinum-Based Compounds: New Strategies; 3.4: Novel Concepts in the Development of Platinum Antitumor Drugs; 3.4.1: Functionalized Single-Walled Carbon Nanotubes (SWNTs) as Vehicles for Delivery of Pt(IV)-Prodrugs; 3.4.2: Targeted Nanoparticles for Delivery of Cisplatin for Prostate Cancer 327 $a3.4.3: Gold Nanoparticles as Delivery Vehicles for Platinum Compounds 330 $aThis book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic. 606 $aPharmaceutical chemistry 606 $aBioinorganic chemistry 608 $aElectronic books. 615 0$aPharmaceutical chemistry. 615 0$aBioinorganic chemistry. 676 $a615.2 701 $aAlessio$b E$g(Enzo)$0982635 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910133642203321 996 $aBioinorganic medicinal chemistry$92242564 997 $aUNINA