LEADER 05146nam 2200601Ia 450 001 9910133221103321 005 20200520144314.0 010 $a3-527-64455-5 010 $a1-283-83536-3 010 $a3-527-63614-5 010 $a3-527-63615-3 035 $a(CKB)3400000000015964 035 $a(EBL)822719 035 $a(SSID)ssj0000550556 035 $a(PQKBManifestationID)11360294 035 $a(PQKBTitleCode)TC0000550556 035 $a(PQKBWorkID)10509320 035 $a(PQKB)10101984 035 $a(MiAaPQ)EBC822719 035 $a(OCoLC)746324309 035 $a(EXLCZ)993400000000015964 100 $a20120427d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMelanins and melanosomes $ebiosynthesis, biogenesis, physiological, and pathological functions /$fby Patrick A. Riley ; edited by Jan Borovansky 210 $aWeinheim : Chichester $cWiley-VCH ; John Wiley [distributor]$dc2011 215 $a1 online resource (431 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32892-0 327 $aMelanins and Melanosomes: Biosynthesis, Biogenesis, Physiological, and Pathological Functions; Dedication; Contents; Preface; List of Contributors; 1: History of Melanosome Research; 1.1 Introduction; 1.2 Melanosome Research in the Pre-Seiji Era; 1.3 Melanosome Research in the Seiji Era; 1.3.1 Terminology of Melanosomes; 1.3.2 Ultrastructural and Histochemical Studies; 1.3.3 Biochemical Studies; 1.4 Melanosome Research in the Post-Seiji Era; 1.5 Other Historical Aspects; Acknowledgments; References; 2: Classical and Nonclassical Melanocytes in Vertebrates; 2.1 Definition of Melanogenic Cells 327 $a2.2 Distribution and Function of Melanogenic Cells2.2.1 Classical Melanocytes; 2.2.1.1 Melanocytes in the Epidermis; 2.2.1.2 Melanocytes in the Dermis; 2.2.1.3 Melanophores in Lower Vertebrates; 2.2.2 Nonclassical Melanocytes; 2.2.2.1 Melanocytes of the Eye; 2.2.2.2 Melanocytes of the Inner Ear; 2.2.2.3 Melanocytes of the Heart; 2.2.2.4 Melanocytes of the Brain and Neuromelanins; 2.2.2.5 Melanin in Adipose Tissue; 2.3 Embryonic Development of Melanogenic Cells; 2.3.1 Classical Melanocytes; 2.3.1.1 Early Determined Melanoblasts: The Dorsolateral Pathway 327 $a2.3.1.2 Late Determined Melanoblasts: A Common Origin with SCPs and the Dorsoventral Migratory Pathway2.3.2 Nonclassical Melanocytes; 2.3.2.1 Melanocytes of the Murine Eye; 2.3.2.2 Melanocytes of the Murine Heart; 2.3.2.3 Other Nonclassical Murine Melanocytes; 2.3.2.4 Other Organisms; 2.4 Transfer of Melanin from Classical and Nonclassical Melanocytes; 2.4.1 Melanosome Transport; 2.4.2 Melanosome Transfer; 2.4.2.1 Melanosome Transfer from Classical Melanocytes; 2.4.2.2 Transfer of Melanin from Nonclassical Melanocytes; References; 3: Biological Chemistry of o-Quinones 327 $a3.1 General Biological Significance of o-Quinones3.1.1 Antibiosis; 3.1.2 Defensive Secretions; 3.1.3 Balanid Adhesion; 3.1.4 Cuticular Hardening in Insects; 3.1.5 Pigmentation; 3.2 o-Quinone Reactivity; 3.2.1 Structure and Reactivity; 3.2.2 Reduction; 3.2.3 Addition Reactions: Intermolecular addition; 3.2.4 Polymerization; 3.2.5 Intramolecular Addition (Cyclization); 3.2.6 Addition-Elimination (Substitution) Reactions; 3.3 Role of o-Quinones in Melanogenesis; 3.3.1 Nonenzymatic Formation of Melanogenic Intermediates 327 $a3.3.1.1 Contributions from Pulse Radiolysis to the Chemistry of Eumelanogenesis and Pheomelanogenesis3.3.2 Balance between Eumelanogenesis and Pheomelanogenesis; 3.3.3 Control of Melanogenesis: Phase I Melanogenesis; 3.3.4 Tyrosinase Activation; 3.3.5 Tyrosinase Inactivation; References; 4: Biosynthesis of Melanins; 4.1 Introduction; 4.2 Raper-Mason Pathway; 4.2.1 Phase I Melanogenesis: The Proximal Raper-Mason Pathway-From L-tyrosine to L-dopachrome; 4.2.2 Distal Melanogenic Steps: From L-Dopachrome to Eumelanins; 4.2.3 Biosynthesis of Pheomelanins 327 $a4.3 Structural and Functional Properties of the Melanogenic Enzymes 330 $aThe surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., - where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, includin 606 $aMelanins 606 $aPigments (Biology) 615 0$aMelanins. 615 0$aPigments (Biology) 676 $a572.59 700 $aRiley$b P. A$g(Patrick Anthony)$0988619 701 $aBorovansky$b Jan$f1943-$0988620 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910133221103321 996 $aMelanins and melanosomes$92260614 997 $aUNINA