LEADER 01379nam 2200397 450 001 9910132620303321 005 20240206104253.0 010 $a1-4123-6346-2 024 7 $a10.1522/030083491 035 $a(CKB)3680000000165513 035 $a(NjHacI)993680000000165513 035 $a(EXLCZ)993680000000165513 100 $a20240206d2008 uy 0 101 0 $afre 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEssai sur l'art de ramper, a? l'usage des courtisans $eface?ties philosophiques tire?es des manuscrits de feu M. le baron d'Holbach /$fPaul Henry Thiry Holbach, F. M. Grimm, Denis Diderot 210 1$aChicoutimi :$cJ.-M. Tremblay,$d2008. 215 $a1 online resource (12 pages) 225 1 $aClassiques des sciences sociales ;$v3270 410 0$aClassiques des sciences sociales ;$v3270. 517 $aEssai sur l'art de ramper à l'usage des courtisans 606 $aCourts and courtiers 615 0$aCourts and courtiers. 676 $a170.44 700 $aHolbach$b Paul Henry Thiry$0758539 702 $aGrimm$b Friedrich Melchior 702 $aDiderot$b Denis 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910132620303321 996 $aEssai sur l'art de ramper, a? l'usage des courtisans$93909950 997 $aUNINA LEADER 04708nam 2201321z- 450 001 9910557356403321 005 20220111 035 $a(CKB)5400000000042325 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76311 035 $a(oapen)doab76311 035 $a(EXLCZ)995400000000042325 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aUbiquitination in Health and Diseases 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (292 p.) 311 08$a3-0365-0546-6 311 08$a3-0365-0547-4 330 $aUbiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled "Ubiquitination in Health and Disease" successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field. 606 $aHumanities$2bicssc 606 $aSocial interaction$2bicssc 610 $aaggregation 610 $aaldosterone sensitive distal nephron 610 $ablood pressure 610 $acancer 610 $acilia 610 $aciliogenesis 610 $aciliopathy 610 $acortical bone derived stem cell 610 $adegradation 610 $adeubiquitinase 610 $adeubiquitinases 610 $adeubiquitination 610 $adifferentiation 610 $adisulfide-coupling 610 $adopa-responsive dystonia 610 $aDUBs 610 $aE3 ubiquitin ligase 610 $aE3s 610 $aendoplasmic reticulum stress 610 $aepithelial sodium channel 610 $aexcitation-transcription coupling 610 $afatty acid-binding protein 3 610 $afibrils 610 $agenetic diseases 610 $ahematopoiesis 610 $ahematopoietic stem cells 610 $aimmune response 610 $aimmune-related diseases 610 $ainflammation 610 $ainhibitor 610 $ainhibitors 610 $ainnate immune 610 $ainterferon 610 $aLUBAC 610 $amesenchymal stem cell 610 $amitochondria 610 $aMITOL/MARCH5 610 $amonoubiquitin signaling 610 $amTOR 610 $amyocardial infarction 610 $aNedd4L/Nedd4-2 610 $aneurodegeneration 610 $aneurodegenerative disease 610 $aNF-?B 610 $aosmotic stress 610 $aParkinson's disease 610 $apolyubiquitin 610 $aproliferation 610 $aproteasomal degradation 610 $aprotein complex formation 610 $aprotein quality control 610 $aprotein stabilization 610 $aproteolysis 610 $aregulation of gene expression 610 $aregulatory T cells 610 $arenal salt reabsorption 610 $aRING finger 610 $aRNF152 610 $aRNF182 610 $aRNF183 610 $aRNF186 610 $asalt-sensitive hypertension 610 $asemisynthesis 610 $atau protein 610 $atherapeutic target 610 $atyrosine hydroxylase 610 $aubiquitin 610 $aubiquitin code 610 $aubiquitin ligase 610 $aubiquitin proteasome system 610 $aubiquitin system 610 $aubiquitin-proteasome pathway 610 $aubiquitin-proteasome system 610 $aubiquitination 610 $aUPS 610 $avascular function 610 $avesicular trafficking 610 $avirus infection 610 $avirus-host interaction 610 $a?-synuclein 615 7$aHumanities 615 7$aSocial interaction 700 $aIshigami$b Tomoaki$4edt$01303374 702 $aIshigami$b Tomoaki$4oth 906 $aBOOK 912 $a9910557356403321 996 $aUbiquitination in Health and Diseases$93026962 997 $aUNINA