LEADER 05527nam 2200697 450 001 9910132397603321 005 20200520144314.0 010 $a1-118-69595-X 010 $a1-118-69593-3 010 $a1-118-69592-5 035 $a(CKB)3710000000355729 035 $a(EBL)1895546 035 $a(SSID)ssj0001421223 035 $a(PQKBManifestationID)11852561 035 $a(PQKBTitleCode)TC0001421223 035 $a(PQKBWorkID)11408911 035 $a(PQKB)10590839 035 $a(MiAaPQ)EBC1895546 035 $a(DLC) 2014040774 035 $a(Au-PeEL)EBL1895546 035 $a(CaPaEBR)ebr11022770 035 $a(CaONFJC)MIL770008 035 $a(OCoLC)897884752 035 $a(PPN)189379758 035 $a(EXLCZ)993710000000355729 100 $a20150305h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHyaluronic acid $epreparation, properties, application in biology and medicine /$fMikhail A. Selyanin, Petr Ya. Boykov and Vladimir N. Khabarov ; translated from the Russian version by scientific editor Felix Polyak 210 1$aChichester, England :$cWiley,$d2015. 210 4$dİ2015 215 $a1 online resource (215 p.) 300 $aDescription based upon print version of record. 311 $a1-118-63379-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aTitle Page; Copyright Page; Contents; Foreword; Introduction; Chapter 1 The History of Hyaluronic Acid Discovery, Foundational Research and Initial Use; 1.1 Discovery; 1.2 Foundational Research; 1.3 Initial Medical Applications; 1.4 Sources of Hyaluronan; 1.5 Current Medical Study and Use; 1.6 Impact and Future Directions; References; Chapter 2 The Biological Role of Hyaluronic Acid; 2.1 Hyaluronic Acid Phylogenesis; 2.1.1 Polysaccharide Structure and the Problems of Phylogenesis; 2.1.2 Physico-Chemical and Functional Differences of Polysaccharides 327 $a2.1.3 Biochemical Features of Hyaluronic Acid and Other Glycosaminoglycans2.2 Functions of Hyaluronan in Human Ontogenesis; 2.2.1 Role of Hyaluronic Acid in Fertilization; 2.2.2 Hyaluronan and Other Glucosaminoglycans in Cell Division, Migration and Differentiation; 2.2.3 Hyaluronic Acid and Sulfated Glycosaminoglycans in Maintaining a Differentiated Status of Cells; 2.2.4 Hyaluronan and Induction of Cellular Cycles for Differentiated Cells; 2.2.5 The Source of Hyaluronic Acid's Functional Properties and the Dynamics of its Synthesis and Degradation 327 $a2.2.6 The Rules of Biopolymer Functional Cleavage2.3 Hyaluronan Signalling Systems; 2.4 Hyaluronan Functions in the Extracellular Matrix; 2.4.1 Extracellular Space; 2.4.2 Composition and Functioning of the Extracellular Matrix; 2.4.3 The Role of Hyaluronan in Transportation of Substances through the Extracellular Matrix: Diffusion, Osmosis, Electro-Osmosis and Vesicular Transportation; 2.4.4 Hyaluronan in the Extracellular Matrix of Different Connective Tissues; References; Chapter 3 Methods of Hyaluronic Acid Production; 3.1 Hyaluronan Sources and Extraction 327 $a3.1.1 Hyaluronan Production from Animal Sources: General Methods3.1.2 Hyaluronan Purification; 3.1.3 The Chemical Production of Hyaluronan from Chicken Combs; 3.1.4 HA Production for Ophthalmology; 3.2 Bacterial Methods of Hyaluronic Acid Production; 3.3 Hyaluronan Destruction during Production, Storage and Sterilization; 3.4 Enzymatic Destruction of Hyaluronan; 3.4.1 Hyaluronidase Classification; 3.4.2 Properties and Functions of Hyaluronidases; 3.5 Non-Enzymatic Destruction of Hyaluronan; 3.5.1 Acid-Base Hydrolysis of Hyaluronan; 3.5.2 Oxidation-Reduction Depolymerization of Hyaluronan 327 $a3.6 Quality of Hyaluronan Commercial Products of Animal and Bacterial OriginReferences; Chapter 4 Molecular and Supramolecular Structure of Hyaluronic Acid; 4.1 Primary Structure of Hyaluronic Acid; 4.2 Structure of Hyaluronan in Solution; 4.3 Rheological Properties of Hyaluronic Acid; References; Chapter 5 Chemical Modifications, Solid Phase, Radio-Chemical and Enzymatic Transformations of Hyaluronic Acid; 5.1 Main Characteristics of Cross-Linked Hydrogels; 5.2 Methods of Hyaluronic Acid Cross-Linking; 5.2.1 Cross-Linking with Carbodiimides; 5.2.2 Cross-Linking with Aldehydes 327 $a5.2.3 Cross-Linking with Divinylsulfone 330 $a Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process. Hyaluronic Acid: Production, Properties, Application inBiology and Medicine consists of six chapters discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical analysis recounts the discovery and milestones of theresearch leading to t 606 $aHyaluronic acid 606 $aOrganic acids 615 0$aHyaluronic acid. 615 0$aOrganic acids. 676 $a612.015782 700 $aSelyanin$b M. A$g(Michael A.),$0956821 702 $aBoykov$b P. Ya 702 $aKhabarov$b V. N$g(Vladimir N.), 702 $aPolyak$b Felix 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910132397603321 996 $aHyaluronic acid$92167072 997 $aUNINA