LEADER 04728nam 2200661 450 001 9910132237603321 005 20200520144314.0 010 $a1-118-83630-8 010 $a1-118-83650-2 010 $a1-118-83632-4 035 $a(CKB)3710000000093187 035 $a(EBL)1650866 035 $a(SSID)ssj0001131966 035 $a(PQKBManifestationID)11627931 035 $a(PQKBTitleCode)TC0001131966 035 $a(PQKBWorkID)11148656 035 $a(PQKB)10800144 035 $a(OCoLC)861789137 035 $a(MiAaPQ)EBC1650866 035 $a(DLC) 2013043100 035 $a(Au-PeEL)EBL1650866 035 $a(CaPaEBR)ebr10849251 035 $a(CaONFJC)MIL584561 035 $a(PPN)224777955 035 $a(EXLCZ)993710000000093187 100 $a20140326h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCyclic-nucleotide phosphodiesterases in the central nervous system $efrom biology to drug discovery /$fedited by Nicholas J. Brandon, Anthony R. West 210 1$aHoboken, New Jersey :$cWiley,$d2014. 210 4$dİ2014 215 $a1 online resource (402 p.) 225 1 $aWiley Series in Drug Discovery and Development 300 $aDescription based upon print version of record. 311 $a0-470-56668-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPhosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin. 330 $aThis book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studi 410 0$aWiley series in drug discovery and development. 606 $aCyclic nucleotide phosphodiesterases 606 $aCentral nervous system$xPhysiology 606 $aNucleotides, Cyclic 615 0$aCyclic nucleotide phosphodiesterases. 615 0$aCentral nervous system$xPhysiology. 615 0$aNucleotides, Cyclic. 676 $a612.01513 702 $aBrandon$b Nicholas J. 702 $aWest$b Anthony R.$f1970- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910132237603321 996 $aCyclic-nucleotide phosphodiesterases in the central nervous system$92173888 997 $aUNINA LEADER 05102nam a2200385Ii 4500 001 991003235839707536 008 070806s2005 ne a sb 001 0 eng d 020 $a9780127639529 020 $a0127639527 035 $ab1365309x-39ule_inst 040 $aBibl. Dip.le Aggr. Ingegneria Innovazione - Sez. Ingegneria Innovazione$beng 082 04$a620.192$222 100 1 $aWool, Richard P.$021801 245 10$aBio-based polymers and composites$h[e-book] /$cRichard P. Wool, Xiuzhi Susan Sun 260 $aAmsterdam ;$aBoston :$bElsevier Academic Press,$cc2005 300 $axix, 620 p. :$bill. ;$c24 cm 504 $aIncludes bibliographical references and index 505 0 $aPreface -- About the Authors -- 1. Overview of Plant Polymers: Resources, Demands, and Sustainability -- 2. Plant Materials Formation and Growth -- 3. Isolation and Processing of Plant Materials -- 4. Polymers and Composite Resins from Plant Oils -- 5. Composites and Foams from Plant Oil-Based Resins -- 6. Fundamentals of Fracture in Bio-Based Polymers -- 7. Properties of Triglyceride-Based Thermosets -- 8. Pressure-Sensitive Adhesives, Elastomers, and Coatings from Plant Oil -- 9. Thermal and Mechanical Properties of Soy Proteins -- 10. Soy Protein Adhesives -- 11. Plastics Derived from Starch and Poly (Lactic Acids) -- 12. Bio-Based Composites from Soybean Oil and Chicken Feathers -- 13. Hurricane-Resistant Houses from Soybean Oil and Natural Fibers -- 14. Carbon Nanotube Composites with Soybean Oil Resins -- 15. Nanoclay Biocomposites -- 16. Lignin Polymers and Composites -- Index 505 0 $aOverview of plant polymers: resources, demands, and sustainability / Xiuzhi Susan Sun -- Plant materials formation and growth / Xiuzhi Susan Sun -- Isolation and processing of plant materials / Xiuzhi Susan Sun -- Polymers and composite resins from plant oils / Richard P. Wool -- Composites and foams from plant oil-based resins / Richard P. Wool -- Fundamentals of fracture in bio-based polymers / Richard P. Wool -- Properties of triglyceride-based thermosets / Richard P. Wool -- Pressure-sensitive adhesives, elastomers, and coatings from plant oil / Richard P. Wool -- Thermal and mechanical properties of soy proteins / Xiuzhi Susan Sun -- Soy protein adhesives / Xiuzhi Susan Sun -- Plastics derived from starch and poly (lactic acids) / Xiuzhi Susan Sun -- Bio-based composites from soybean oil and chicken feathers / Richard P. Wool -- Hurricane-resistant houses from soybean oil and natural fibers / Richard P. Wool -- Carbon nanotube composites with soybean oil resins / Richard P. Wool -- Nanoclay biocomposites / Richard P. Wool -- Lignin polymers and composites / Richard P. Wool 520 $aBio-Based Polymers and Composites is the first book systematically describing the green engineering, chemistry and manufacture of biobased polymers and composites derived from plants. This book gives a thorough introduction to bio-based material resources, availability, sustainability, biobased polymer formation, extraction and refining technologies, and the need for integrated research and multi-disciplinary working teams. It provides an in-depth description of adhesives, resins, plastics, and composites derived from plant oils, proteins, starches, and natural fibers in terms of structures, properties, manufacturing, and product performance. This is an excellent book for scientists, engineers, graduate students and industrial researchers in the field of bio-based materials. * First book describing the utilization of crops to make high performance plastics, adhesives, and composites * Interdisciplinary approach to the subject, integrating genetic engineering, plant science, food science, chemistry, physics, nano-technology, and composite manufacturing. * Explains how to make green materials at low cost from soyoil, proteins, starch, natural fibers, recycled newspapers, chicken feathers and waste agricultural by-products 533 $aElectronic reproduction.$bAmsterdam :$cElsevier Science & Technology,$d2007.$nMode of access: World Wide Web.$nSystem requirements: Web browser.$nTitle from title screen (viewed on Aug. 2, 2007).$nAccess may be restricted to users at subscribing institutions 650 0$aPlant polymers 650 0$aBiopolymers 650 0$aPlants$xComposition 655 7$aElectronic books.$2local 700 1 $aSun, Xiuzhi Susan$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0738213 776 1 $cOriginal$z0127639527$z9780127639529$w(DLC) 2005013910$w(OCoLC)60514999 856 40$3Referex$uhttp://www.sciencedirect.com/science/book/9780127639529$zAn electronic book accessible through the World Wide Web; click for information 856 41$zTable of contents only$uhttp://www.loc.gov/catdir/toc/ecip0513/2005013910.html 856 42$zPublisher description$uhttp://catdir.loc.gov/catdir/enhancements/fy0622/2005013910-d.html 907 $a.b1365309x$b03-03-22$c24-01-08 912 $a991003235839707536 996 $aBio-based polymers and composites$91462067 997 $aUNISALENTO 998 $ale026$b24-01-08$cm$d@ $e-$feng$gne $h0$i0