LEADER 05473nam 2200673 450 001 9910132190303321 005 20170821200515.0 010 $a3-527-68335-6 010 $a3-527-68332-1 010 $a3-527-68334-8 035 $a(CKB)3710000000202707 035 $a(EBL)1744761 035 $a(OCoLC)884646511 035 $a(SSID)ssj0001412029 035 $a(PQKBManifestationID)12004780 035 $a(PQKBTitleCode)TC0001412029 035 $a(PQKBWorkID)11406363 035 $a(PQKB)10500042 035 $a(MiAaPQ)EBC1744761 035 $a(EXLCZ)993710000000202707 100 $a20140815h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIndustrial scale suspension culture of living cells /$fedited by Hans-Peter Meyer and Diego R. Schmidhalter 210 1$aWeinheim, Germany :$cWiley-Blackwell,$d2014. 210 4$dİ2014 215 $a1 online resource (644 p.) 300 $aDescription based upon print version of record. 311 $a1-322-47555-5 311 $a3-527-33547-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIndustrial Scale Suspension Culture of Living Cells; Forword; Contents; Preface; List of Contributors; The History and Economic Relevance of Industrial Scale Suspension Culture of Living Cells; 1 Introduction; 2 A Short History of Suspension Culture (Fermentation); 2.1 Ethanol, Organic Acids, and Solvents, the Beginning; 2.2 Vitamins Fermentation Takes a Long Time to Develop; 2.3 Steroids, the First Large-Scale Biocatalysis Processes; 2.4 Antibiotics, a US-Lead Turning Point in Fermentation Technology; 2.5 Amino Acids, a Japanese Fermentation Success Story 327 $a2.6 Enzymes, a European Fermentation Success Story2.7 Single Cell Proteins, an Economic Flop; 2.8 Biofuels are Controversial Story; 2.9 Recombinant DNA Technology Based Products (Monoclonal Antibodies and Other Recombinant Proteins), Setting off an Avalanche of New Products; 3 The Contemporary Situation; 3.1 How Long Can the USA Keep its Leading Role?; 3.2 China and India Become Global Forces in Fermentation; 4 The Future of Suspension Culture; 4.1 New Frontiers; 4.2 Yet "Uncultured" Cells and Organisms?; 5 Economic and Market Considerations; 5.1 The Pharmaceutical Market 327 $a5.2 Personal Care Products5.3 Chemicals, Industrial and Technical Enzymes; 5.4 Food, Dietary Supplements (Functional Food, Nutraceuticals), and Feed Products; 6 Conclusions; References; Part I: Suspension Culture of Bacteria, Yeasts, and Filamentous Fungi; 1 Bacterial Suspension Cultures; 1.1 Introduction; 1.2 Organisms, Cells, and their Products; 1.2.1 Bacteria as Production Platform for Various Products; 1.2.2 Historical Outline for Escherichia coli; 1.2.3 Industrial Aspects of Bacterial Expression Systems; 1.3 Bioprocess Design Aspects for Recombinant Products 327 $a1.3.1 Bacterial Cultivation Processes1.3.2 Gram Negative Cell Factory: Cellular Compartments and Transport across Membranes; 1.3.3 Industrial Strategies: Quality, Folding State, and Location of Recombinant Protein Products; 1.3.4 Approaches towards Bioprocess Design, Optimization, and Manufacturing; 1.3.5 Bacterial Bioprocess Design; 1.3.5.1 Technical and Physiological Constraints for Bacterial Bioprocess Design; 1.3.5.2 Media Design; 1.3.5.3 Product Titer is Determined by the Biomass Concentration and the Specific Productivity qp; 1.3.6 Industrial Production Strategy by Two-Step Cultivation 327 $a1.3.6.1 Batch Phase for the Accumulation of Biomass1.3.6.2 Structured Approach Towards Batch Design; 1.3.6.3 Fed-Batch Phase Process Design from Scratch; 1.3.6.4 Induction Phase: Product Formation Characteristics; 1.3.6.5 Process Parameters Impacting Recombinant Product Formation; 1.3.6.6 Concept of Time-Space Yield; 1.4 Basic Bioreactor Design Aspects; 1.4.1 Introduction; 1.4.2 Vessel Design and Construction; 1.4.3 Dimensioning; 1.4.3.1 Materials of Construction; 1.4.3.2 Surface Quality and Welding; 1.4.3.3 Nozzles and Ports; 1.4.4 Mass Transfer; 1.4.5 Cleaning in Place 327 $a1.4.6 Steaming in Place 330 $a The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry i 606 $aIndustrial microbiology$xMethodology 606 $aCell culture$xIndustrial applications 606 $aBiotechnology$vJuvenile literature 608 $aElectronic books. 615 0$aIndustrial microbiology$xMethodology. 615 0$aCell culture$xIndustrial applications. 615 0$aBiotechnology 676 $a611 676 $a611/.01816 702 $aMeyer$b Hans-Peter 702 $aSchmidhalter$b Diego R. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910132190303321 996 $aIndustrial scale suspension culture of living cells$92029004 997 $aUNINA