LEADER 05944nam 2200781 450 001 9910132150703321 005 20200520144314.0 010 $a1-118-87281-9 010 $a1-118-87280-0 010 $a1-118-87282-7 035 $a(CKB)3710000000220697 035 $a(EBL)1762790 035 $a(SSID)ssj0001289799 035 $a(PQKBManifestationID)12528507 035 $a(PQKBTitleCode)TC0001289799 035 $a(PQKBWorkID)11233698 035 $a(PQKB)10061241 035 $a(PQKBManifestationID)16040700 035 $a(PQKB)22038905 035 $a(OCoLC)891385869 035 $a(MiAaPQ)EBC1762790 035 $a(DLC) 2014016529 035 $a(Au-PeEL)EBL1762790 035 $a(CaPaEBR)ebr10915571 035 $a(CaONFJC)MIL639083 035 $a(OCoLC)878224572 035 $a(PPN)224667971 035 $a(EXLCZ)993710000000220697 100 $a20140903h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStrategies for reducing drug and chemical residues in food animals $einternational approaches to residue avoidance, management, and testing /$fedited by Ronald E. Baynes, Jim E. Riviere ; contributors, Glen Almond [and nineteen others] 210 1$aHoboken, New Jersey :$cWiley,$d2014. 210 4$dİ2014 215 $a1 online resource (697 p.) 300 $aDescription based upon print version of record. 311 $a1-322-07832-7 311 $a0-470-24752-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title page; Copyright page; Preface; Contributors; 1 Importance of Veterinary Drug Residues; 1.1 Introduction; 1.2 Veterinary Drug Use in Livestock; 1.3 Quality Assurance Programs; 1.4 Adverse Human Health Effects of Drug Residues; 1.5 Withdrawal Time Determinations; 1.6 Antimicrobial Resistance; 1.7 Economic Impact of Drug Residues; References; 2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination of Withdrawal Periods for Animal Drugs; 2.1 Introduction; 2.2 Basic Pharmacokinetic Principles Underlying Drug Depletion 327 $a2.3 The Impact of PK on Drug Depletion2.4 Factors Influencing ADME; 2.5 Conclusion; References; 3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals for Establishing Withdrawal Periods and Milk Discard Times; 3.1 Introduction; 3.2 Information Needed for Determination of Withdrawal Periods or Milk Discard Times; 3.3 Factors for Consideration in Conducting a Marker Residue Depletion Study; References; Acknowledgments; 4 Establishing Maximum Residue Limits in Europe; 4.1 Introduction; 4.2 Procedure for the Establishment of MRLs; 4.3 Scientific Evaluation 327 $a4.4 Extrapolation of MRLs4.5 Prohibited Drugs; 4.6 EU Policy on Minor Use and Minor Species; 4.7 EU Policy and Legislation on Feed Additives; 4.8 Off-Label Use; References; Acknowledgments; 5 Methods to Derive Withdrawal Periods in the European Union; 5.1 Introduction; 5.2 Withdrawal Periods for Meat; 5.3 Statistical Method; 5.4 Alternative Approach: Decision Rule; 5.5 Withdrawal Periods for Milk; 5.6 Withdrawal Periods for Eggs; 5.7 Withdrawal Periods for Honey; 5.8 Extrapolation of Withdrawal Periods; References; 6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 327 $a6.1 Introduction6.2 Applications of Population Modeling to Preslaughter Withdrawal Times; 6.3 Covariate Analysis; 6.4 Benefits to Population-Based Modeling Techniques; 6.5 Limitations of Population-Based Modeling Techniques; 6.6 Future Applications; 6.7 Conclusions; References; 7 Physiologically Based Pharmacokinetic Modeling; 7.1 Introduction; 7.2 Model Development and Validation; 7.3 PBPK Applied to Prediction of Drug Residues; 7.4 Conclusions; References; 8 Residue Avoidance in Beef Cattle Production Systems; 8.1 Introduction; 8.2 Beef Cattle Production Systems 327 $a8.3 Use of Anti-infective Agents in Beef Cattle Production8.4 Approaches to Minimize the Need for Antimicrobial Drugs; 8.5 Approaches to Minimize the Need for Parasiticides; 8.6 Approaches to Minimize Residues (Residue Avoidance); 8.7 Quality Assurance Programs; 8.8 The Future: Antimicrobial Regulation and the Market for "Antimicrobial-Free" Beef Products; References; 9 Residue Avoidance in Dairy Cattle Production Systems; 9.1 Prophylactic Use of Drugs in Dairy Cattle; 9.2 Therapeutic Use of Drugs in Dairy Cattle; 9.3 Prevalence of Drug Residues; 9.4 Minimizing Residues in Meat and Milk 327 $aReferences 330 $aHighlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. Focuses attention on drug and chemical residues in edible animal products Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animals Details major drug classes used in food animal production and their residue risks Highlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and 606 $aFood animals$xFeeding and feeds$xContamination 606 $aFood animals$xNutrition 606 $aVeterinary drug residues 606 $aAnimal nutrition 615 0$aFood animals$xFeeding and feeds$xContamination. 615 0$aFood animals$xNutrition. 615 0$aVeterinary drug residues. 615 0$aAnimal nutrition. 676 $a636.08/5 702 $aBaynes$b Ronald 702 $aRiviere$b J. Edmond$g(Jim Edmond), 702 $aAlmond$b Glen 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910132150703321 996 $aStrategies for reducing drug and chemical residues in food animals$92113789 997 $aUNINA