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100   $a20160829d2014      fy             0
101 0 $aeng
135   $aur||#||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 04$aThe origin, function and diagnostic potential of extracellular microRNA in human body fluids  /$ftopic editors: Andrey Turchinovich and William Cho
210   $cFrontiers Media SA$d2014
210 31$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d[2014]
210  4$dİ2014
215   $a1 online resource (114 pages) $cillustrations; digital file(s)
225 1 $aFrontiers Research Topics,$x1664-8714
300   $aBibliographic Level Mode of Issuance: Monograph
300   $a"Published in: Frontiers in genetics" -- front cover.
311 08$aPrint version: 2889192423 
320   $aIncludes bibliographical references.
330   $aShort non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific 'by-products' of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication.
410  0$aFrontiers research topics.
606   $aMicroRNA
606   $aBlood plasma
606   $aBlood$xDiseases
606   $aGenetics
606   $aEpigenetics
606   $aHematologic Diseases$2HILCC
606   $aMedicine$2HILCC
606   $aHealth & Biological Sciences$2HILCC
610   $aextracellular miRNA
610   $aexosomal miRNA
610   $ablood plasma
610   $ablood serum
610   $acirculating miRNA
610   $aArgonaute Proteins
610   $acell-cell communication
610   $abiological fluids
615  0$aMicroRNA.
615  0$aBlood plasma.
615  0$aBlood$xDiseases.
615  0$aGenetics.
615  0$aEpigenetics.
615  7$aHematologic Diseases
615  7$aMedicine
615  7$aHealth & Biological Sciences
700   $aWilliam Cho$4auth$01364863
702   $aTurchinovich$b Andrey
702   $aCho$b William C. S.
801  0$bPQKB
801  2$bUkMaJRU
906   $aBOOK
912   $a9910131532303321
996   $aThe origin, function and diagnostic potential of extracellular microRNA in human body fluids$93386306
997   $aUNINA