LEADER 04462nam 2200637 450 001 9910131532103321 005 20230621140410.0 010 $a9782889192380$b(ebook) 035 $a(CKB)3710000000504556 035 $a(SSID)ssj0001680347 035 $a(PQKBManifestationID)16496203 035 $a(PQKBTitleCode)TC0001680347 035 $a(PQKBWorkID)15028422 035 $a(PQKB)10111740 035 $a(WaSeSS)IndRDA00056339 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53528 035 $a(EXLCZ)993710000000504556 100 $a20160829d2014 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMind the gap! $egap junction channels and their importance in pathogenesis /$ftopic editors: Aida Salameh, Katja Blanke and Stefan Dhein 210 $cFrontiers Media SA$d2014 210 31$aFrance :$cFrontiers Media SA,$d2014 215 $a1 online resource (252 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a2-88919-238-5 330 $a?Cells live together, but die singly?, this sentence wrote the German physiologist Theodor Engelmann in 1875 and although he had no particular knowledge of gap junction channels (their structure was discovered around 100 years later) he described their functions very well: gap junction channels are essential for intercellular communication and crucial for the development of tissue and organs. But besides providing an opportunity for cells to communicate gap junction channels might also prevent intercellular communication by channel closure thereby preserving the surrounding healthy tissue in case of cellular necrosis. According to today?s understanding gap junction channels play an important role during embryonic development, during growth, wound healing and cell differentiation and are also involved in the process of learning. In the past decades most intensive research was done not only to unravel the physiological role of gap junction channels but also to extend our knowledge of the contribution of these channels in pathogenesis. A new frontier emerges in the field ?pharmacology of gap junctions? with the aim to control growth, differentiation, or electrical coupling via targeting gap junction channels pharmacologically.As we know today disturbances in gap junction synthesis, assembly and cellular distribution may account for various organic disorders from most different medical fields, such as the Charcot-Marie-Tooth neuropathy, epilepsy, Chagas-disease, Naxos-syndrome, congenital cardiac malformations, arrhythmias, cancer and as a very common disease in industrial countries atherosclerosis. Point mutations in gap junction channels have been found to cause hereditary diseases like the congenital deafness or the Charcot-Marie-Tooth neuropathy but the exact molecular mechanisms of gap junction malfunction from most of the mentioned illnesses are not fully understood. Moreover, in the last few years research has expanded on the role and function of connexin hemichannels and on a relatively new field the pannexins. The purpose of this volume is to give a comprehensive overview of the involvement of gap junction channels, hemichannels and pannexins on pathogenesis of inborn and acquired diseases and on emerging pharmacological strategies to target these channels.We welcome our colleagues to contribute their findings on the influence of gap junctions on pathogenesis and to unravel the secrets of intercellular communication. Take the lid off! 606 $aCytology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $adevelopment 610 $adifferentiation 610 $aGrowth 610 $apannexins 610 $aintercellular communication 610 $ahemichannels 610 $aConnexins 610 $agap junction 610 $aPharmacology 610 $ahuman diseases 615 7$aCytology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aStefan Dhein$4auth$01366877 702 $aSalameh$b Aida 702 $aDhein$b S 702 $aBlanke$b Katja 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910131532103321 996 $aMind the gap$93389396 997 $aUNINA