LEADER 03190oam 2200613 450 001 9910131531503321 005 20230807201904.0 035 $a(CKB)3710000000504559 035 $a(SSID)ssj0001666880 035 $a(PQKBManifestationID)16455795 035 $a(PQKBTitleCode)TC0001666880 035 $a(PQKBWorkID)15001023 035 $a(PQKB)11783531 035 $a(WaSeSS)IndRDA00056559 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43627 035 $a(EXLCZ)993710000000504559 100 $a20160829d2015 fy 0 101 0 $aeng 135 $aurmn#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aComparative studies between HTLV-1 and HTLV-2 function and pathobiology$b[electronic resource] /$ftopic editors Umberto Bertazzoni and Françoise Bex 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2015. 210 4$dİ2015 215 $a1 online resource (94 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers research topics 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a2-88919-498-1 320 $aIncludes bibliographical references. 330 $aHuman T-cell leukemia viruses 1 and 2 (HTLV-1 and HTLV-2) have similar genomic structure but differ in pathogenicity. HTLV-1 is associated with ATL whereas HTLV-2 has not been linked to lymphoproliferative diseases. A comparative analysis between the two viruses is important to reach a better understanding of the difference in pathogenesis. A key role is attributed to the Tax proteins; Tax-1 function and structure has been thoroughly investigated but less is known about Tax-2. Recent studies on HTLV-1 and HTLV-2 expression strategies highlighted converging patterns as well as peculiar differences in the expression of regulatory proteins that might influence the pathobiology of these viruses. The study of interaction of regulatory proteins with cellular pathways factors has opened new avenues in understanding the mechanisms of gene transcription and deregulation. However, further investigation is needed on the role on innate immunity on HTLV-1 and HTLV-2 pathogenesis. Concerning the mechanisms of infection and related diseases and of their interaction with other co-infecting agents, the comparison between HTLV-1 and HTLV-2 needs further investigation. 606 $aMicrobiology 606 $aMicrobiology & Immunology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aProteins 610 $aCo-infection 610 $aExpression 610 $aHTLV-1 610 $aHTLV-2 615 0$aMicrobiology. 615 7$aMicrobiology & Immunology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aFrancoise Bex$4auth$01376134 702 $aBertazzoni$b Umberto 702 $aBex$b Françoise 801 0$bPQKB 801 2$bUkMaJRU 906 $aBOOK 912 $a9910131531503321 996 $aComparative studies between HTLV-1 and HTLV-2 function and pathobiology$93411467 997 $aUNINA