LEADER 03223nam 2200589 450 001 9910131530803321 005 20230621140742.0 010 $a9782889194971$b(ebook) 035 $a(CKB)3710000000504563 035 $a(SSID)ssj0001680233 035 $a(PQKBManifestationID)16496142 035 $a(PQKBTitleCode)TC0001680233 035 $a(PQKBWorkID)15028173 035 $a(PQKB)11152216 035 $a(WaSeSS)IndRDA00056199 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53244 035 $a(EXLCZ)993710000000504563 100 $a20160829d2015 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMetal economy in host-microbe interactions /$ftopic editors: Frédéric Veyrier and Mathieu Cellier 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (215 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aFrom simple inorganic catalysts to vital biological cofactors, divalent transition metals are instrumental to electron transfers, catalysis and signalling. Their natural ability to bind, exchange and react with organic molecules including oxygen requires from living cells to regulate uptake with metabolic activities, sensing and chaperoning, distributing and storing, or excreting excess to prevent detrimental biochemical reactions. Since transition metal deficiency and overload both limit cell growth it is no surprise that the immune system evolved a dual strategy, of metal starvation or intoxication, to thwart microbial invasions. Like environmental metal availability determined biological use it also shaped host-microbe metal economy: Fe and Mn, available early in evolution and still required rather ubiquitously, are generally withheld by host in response to infection; Zn and Cu, which became bioavailable later, essentially to eukaryotic cells may be bombarded toward invaders. Successful microbial pathogens have evolved elaborate counter-measures to cope with host metal defenses. This research topic aims to review and discuss metal currencies in host-microbe interactions focusing on new findings about micro-organism pathogenesis determinants in the face of host innate strategies to interfere with microbial physiology. 606 $aMicrobiology & Immunology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aexporter 610 $aregulation 610 $aVirulence 610 $atransporter 610 $ametal 610 $ahost 610 $apathogen 615 7$aMicrobiology & Immunology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aFrederic Veyrier$4auth$01364350 702 $aCellier$b Mathieu 702 $aVeyrier$b Frédéric 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910131530803321 996 $aMetal economy in host-microbe interactions$93385548 997 $aUNINA