LEADER 03665nam 2200565 450 001 9910131530003321 005 20230621140716.0 010 $a9782889194841 (ebook) 035 $a(CKB)3710000000504567 035 $a(SSID)ssj0001680186 035 $a(PQKBManifestationID)16496090 035 $a(PQKBTitleCode)TC0001680186 035 $a(PQKBWorkID)15028267 035 $a(PQKB)11156211 035 $a(WaSeSS)IndRDA00056125 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52684 035 $a(EXLCZ)993710000000504567 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aManipulation of the host cell by viral auxiliary proteins /$ftopic editors Nadine Laguette and Monsef Benkirane 210 $cFrontiers Media SA$d2015 210 31$aSwitzerland :$cFrontiers Media SA,$d2015 215 $a1 online resource (118 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aProductive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of cellular factors/pathways to the benefit of the viral life cycle. To gain a foothold into host cells, HIV has to take advantage of available cellular factories and overcome the numerous potential blocks opposed to its replication while ensuring cellular survival. Viral auxiliary proteins are a perfect paradigm to illustrate the complexity of the relationship between HIV and its host. Although these accessory proteins are mostly unnecessary for viral replication in permissive cells in vitro, they play a crucial role in regulating viral spread ex vivo in non-permissive cells and in vivo in hosts. Most accessory proteins are pleiotropic and instrumental in the counteraction of restriction factors and proteins involved in innate immune response.Several proteins of the ?intrinsic? immune system that detect the presence of the assailant and initiate a subsequent immune response, as well as restriction factors that are directly devoted to arresting the replication cycle at precise steps have been characterized. Despite the numerous cellular mechanisms dedicated to preventing viral replication, HIV is able to efficiently replicate in humans. Indeed, as a master regulator of cellular machineries and processes, not only has HIV evolved strategies to avoid triggering of pattern recognition receptors, but HIV has also elaborated ways to counteract host restriction factors, thereby overcoming the hurdles that oppose efficient replication. 606 $aMicrobiology & Immunology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aHIV 610 $aintracellular sensors 610 $arestriction factors 610 $aintrinsic immune system 610 $aViral accessory proteins 615 7$aMicrobiology & Immunology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aNadine Laguette$4auth$01365043 702 $aBenkirane$b Monsef 702 $aLaguette$b Nadine 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910131530003321 996 $aManipulation of the host cell by viral auxiliary proteins$93386699 997 $aUNINA