LEADER 02567nam 2200433z- 450 001 9910131529303321 005 20230221130312.0 035 $a(CKB)3710000000504571 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40172 035 $a(EXLCZ)993710000000504571 100 $a20202102d2015 |y e 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdult neurogenesis twenty years later: physiological function versus brain repair 210 $cFrontiers Media SA$d2015 215 $a1 electronic resource (120 p.) 225 1 $aFrontiers Research Topics 311 $a2-88919-494-9 330 $aThe discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes. 517 $aAdult neurogenesis twenty years later 610 $aNeurodegenerative Diseases 610 $astructural plasticity 610 $abrain repair 610 $aCell specification 610 $acell therapy 610 $acell migration 610 $abrain evolution 610 $aNeural Stem Cells 610 $aRegenerative Medicine 610 $atherapeutic approaches 700 $aPaolo Peretto$4auth$01287760 702 $aLuca Bonfanti$4auth 906 $aBOOK 912 $a9910131529303321 996 $aAdult neurogenesis twenty years later: physiological function versus brain repair$93020360 997 $aUNINA