LEADER 05062nam 2200733 450 001 9910131471703321 005 20200520144314.0 010 $a1-118-93697-3 010 $a1-118-93699-X 010 $a1-118-93698-1 035 $a(CKB)3710000000476437 035 $a(EBL)4093343 035 $a(SSID)ssj0001553127 035 $a(PQKBManifestationID)16170925 035 $a(PQKBTitleCode)TC0001553127 035 $a(PQKBWorkID)14812729 035 $a(PQKB)10558905 035 $a(PQKBManifestationID)16176183 035 $a(PQKB)22566357 035 $a(MiAaPQ)EBC4093343 035 $a(DLC) 2015034222 035 $a(Au-PeEL)EBL4093343 035 $a(CaPaEBR)ebr11119457 035 $a(OCoLC)936865300 035 $a(PPN)204669774 035 $a(EXLCZ)993710000000476437 100 $a20151209h20162016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe treatment of epilepsy /$fedited by Simon Shorvon, Emilio Perucca, Jerome Engel, Jr. ; contributors, Patrick Adjei [and one hundred thirty others] 205 $aFourth edition. 210 1$aChichester, England :$cWiley Blackwell,$d2016. 210 4$dİ2016 215 $a1 online resource (2765 p.) 300 $aDescription based upon print version of record. 311 $a1-118-93700-7 320 $aIncludes bibliographical references and index. 327 $aTitle page; Copyright; List of Contributors; Preface to the Fourth Edition; Preface to the First Edition; Historical Introduction The Drug Treatment of Epilepsy from 1857 to 2015; Commentary; Acknowledgement; References; Section I Introduction; 1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE; Definition; Classification; The future of classification schemes of epilepsy; Definition; Definition and classification - status epilepticus; Afterthought; Acknowledgement; References 327 $a2 Differential Diagnosis of EpilepsyIntroduction; General approach to the diagnosis of episodic disturbances; Syncope; Non-epileptic seizures; Panic disorder; Migraine; Sleep disorders; Vertigo; Movement disorders; Cerebral ischaemia; Endocrine and metabolic abnormalities; Transient global amnesia; References; 3 Mechanisms of Epileptogenesis; Membrane ion channels; Membrane ion channels as targets for antibodies in acquired autoimmune disorders; Network and system involvement in epileptogenesis; Epileptogenesis as a process; New targets for antiepileptic and antiepileptogenic strategies 327 $aConclusionsReferences; 4 Antiepileptic Drug Discovery; Characteristics of the ideal model system; The current era of AED discovery; Anticonvulsant Screening Program; Early identification of antiepileptic activity; MES, scPTZ and 6-Hz tests; Differentiation of anticonvulsant activity; Pharmacological profile and potential clinical utility; Pharmacoresistant seizure models; Therapeutic index and toxicity assessment; Aetiologically relevant model systems; Beyond the seizure; Antiepileptogenesis and disease modification (see also Chapter 8); Conclusions; Acknowledgement; References 327 $a5 Antiepileptic Drug DevelopmentIntroduction; Overview on clinical studies and trials for drug development; Opportunities for developing better antiseizure AEDs; Development of epilepsy drugs beyond suppressing seizures; Conclusions; Acknowledgements; References; 6 Mechanisms of Antiepileptic Drug Action; Main targets; Other targets; References; 7 Mechanisms of Drug Resistance and Tolerance; Introduction; The concept of drug resistance in epilepsy; Disease-related mechanisms of drug resistance in epilepsy; Drug-related mechanisms of drug resistance in epilepsy 327 $aPharmacogenetic mechanisms of drug resistance in epilepsyProof-of-concept of drug resistance hypotheses; Conclusions; References; 8 Epilepsy Biomarkers; Introduction; Need for biomarkers; Mechanisms of epilepsy; Potential biomarkers; Research to identify biomarkers; Acknowledgements; References; Section II Principles of Medical Management; 9 General Principles of Medical Management; Aims of treatment; When should treatment be started?; Initiation of treatment and dose optimization; Assessing clinical response; What next when the initial treatment fails? - monotherapy and combination therapy 327 $aHow long should treatment be continued? 606 $aEpilepsy$xSurgery 606 $aAnticonvulsants$xTherapeutic use 606 $aEpilepsy$xChemotherapy 615 0$aEpilepsy$xSurgery. 615 0$aAnticonvulsants$xTherapeutic use. 615 0$aEpilepsy$xChemotherapy. 676 $a617.481 702 $aShorvon$b S. D$g(Simon D.), 702 $aPerucca$b Emilio 702 $aEngel$b Jerome$cJr., 702 $aAdjei$b Patrick 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910131471703321 996 $aTreatment of epilepsy$9805515 997 $aUNINA