LEADER 03658nam 2200613 450 001 9910131367903321 005 20210209120854.0 010 $a1-118-74358-X 010 $a1-118-74361-X 010 $a1-118-74360-1 035 $a(CKB)3710000000437616 035 $a(EBL)2078736 035 $a(SSID)ssj0001515346 035 $a(PQKBManifestationID)12599473 035 $a(PQKBTitleCode)TC0001515346 035 $a(PQKBWorkID)11481642 035 $a(PQKB)10941382 035 $a(PQKBManifestationID)16047593 035 $a(PQKB)21938953 035 $a(MiAaPQ)EBC4038260 035 $a(DLC) 2015001540 035 $a(MiAaPQ)EBC2078736 035 $a(Au-PeEL)EBL2078736 035 $a(OCoLC)900194579 035 $a(PPN)190246790 035 $a(EXLCZ)993710000000437616 100 $a20150708h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIbuprofen $ediscovery, development and therapeutics /$fedited by K. D. Rainsford, Biomedical Research Centre, Sheffield Hallam University, UK 205 $a1st ed. 210 1$aChichester, West Sussex, United Kingdom :$cWiley-Blackwell,$d2015. 210 4$dİ2015 215 $a1 online resource (623 p.) 300 $aDescription based upon print version of record. 311 $a1-118-74338-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aHistory and development of ibuprofen / K.D. Rainsford -- The medicinal chemistry of ibuprofen / K.J. Nichol and D.W. Allen -- The pharmaceutics of iIbuprofen / F. Higton -- The pharmacokinetics of iIbuprofen in humans and animals / D.R. Brocks and F. Jamali -- Pharmacology and toxicology of ibuprofen / K.D. Rainsford -- Therapeutics of ibuprofen in rheumatic and other chronic and painful diseases / W.F. Kean, the late W.W. Buchanan and K.D. Rainsford -- Safety and efficacy of non-prescription (OTC) ibuprofen / K.D. Rainsford -- Use of ibuprofen in dentistry / R.A. Dionne, S.A. Gordon and S.A. Cooper -- Gastrointestinal adverse drug reactions attributed to ibuprofen / K.D. Rainsford and I.G. Bjarnason -- Hepatic and renal effects of ibuprofen / K.D. Rainsford -- Adverse drug reactions attributed to ibuprofen : effects other than gastrointestinal / L.J. Miwa, M. Maneno and J.K. Jones -- Human toxicity of ibuprofen / G.N. Volans -- Ibuprofen in the prevention and therapy of cancer / R.E. Harris -- Ibuprofen in the prevention and treatment of neurodegenerative diseases / K.D. Rainsford -- Appendix I : some brands of iIbuprofen available worldwide / K.D. Rainsford -- Appendix II : methods for the analysis of ibuprofen in biological fluids / K.D. Rainsford. 330 $aIbuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific adviso 606 $aIbuprofen 615 0$aIbuprofen. 676 $a615.7 676 $a615.783 702 $aRainsford$b K. D.$f1941- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910131367903321 996 $aIbuprofen$91990208 997 $aUNINA