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035   $a(PQKBTitleCode)TC0001680122
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035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45324
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100   $a20160829d2015      uy             |
101 0 $aeng
135   $aur|||||||||||
181   $ctxt
182   $cc
183   $acr
200 00$aDNA helicases$b[electronic resource] $eexpression, functions and clinical implications /$ftopic editors Fumiaki Uchiumi, Masayuki Seki and Yasuhiro Furuichi
210   $cFrontiers Media SA$d2015
210 31$aFrance :$cFrontiers Media SA,$d2015
215   $a1 online resource (78 pages) $cillustrations, colour charts
225 0 $aFrontiers Research Topics
300   $aBibliographic Level Mode of Issuance: Monograph
320   $aIncludes bibliographical references.
330   $aHelicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.
606   $aAnimal Biochemistry$2HILCC
606   $aHuman Anatomy & Physiology$2HILCC
606   $aHealth & Biological Sciences$2HILCC
610   $aDNA Repair
610   $aAging
610   $ahelicases
610   $aTelomere
610   $aCancer
615  7$aAnimal Biochemistry
615  7$aHuman Anatomy & Physiology
615  7$aHealth & Biological Sciences
700   $aFumiaki Uchiumi$4auth$01365041
702   $aFuruichi$b Yasuhiro
702   $aUchiumi$b Fumiaki
702   $aSeki$b Masayuki
801  0$bPQKB
801  2$bUkMaJRU
912   $a9910131367303321
996   $aDNA helicases$93386697
997   $aUNINA