LEADER 05400nam 22006734a 450 001 9910143582603321 005 20170809162043.0 010 $a1-280-72166-9 010 $a9786610721665 010 $a0-470-08795-1 010 $a0-470-08794-3 035 $a(CKB)1000000000355408 035 $a(EBL)281847 035 $a(OCoLC)476027151 035 $a(SSID)ssj0000174659 035 $a(PQKBManifestationID)11171696 035 $a(PQKBTitleCode)TC0000174659 035 $a(PQKBWorkID)10174632 035 $a(PQKB)10516282 035 $a(MiAaPQ)EBC281847 035 $a(EXLCZ)991000000000355408 100 $a20060523d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHPLC for pharmaceutical scientists$b[electronic resource] /$fedited by Yuri Kazakevich, Rosario LoBrutto 210 $aHoboken, N.J. $cWiley-Interscience$dc2007 215 $a1 online resource (1136 p.) 300 $aDescription based upon print version of record. 311 $a0-471-68162-8 320 $aIncludes bibliographical references and indexes. 327 $aHPLC FOR PHARMACEUTICAL SCIENTISTS; CONTENTS; PREFACE; CONTRIBUTORS; PART I HPLC THEORY AND PRACTICE; 1 Introduction; 1.1 Chromatography in the Pharmaceutical World; 1.2 Chromatographic Process; 1.3 Classification; 1.4 History of Discovery and Early Development (1903-1933); 1.5 General Separation Process; 1.5.1 Modern HPLC Column; 1.5.2 HPLC System; 1.6 Types of HPLC; 1.6.1 Normal-Phase Chromatography (NP HPLC); 1.6.2 Reversed-Phase HPLC (RP HPLC or RPLC); 1.6.3 Ion-Exchange Chromatography (IEX); 1.6.4 Size-Exclusion Chromatography (SEC); 1.7 HPLC Descriptors (Vr, k, N, etc.) 327 $a1.7.1 Retention Volume1.7.2 Void Volume; 1.7.3 Retention Factor; 1.7.4 Selectivity; 1.7.5 Efficiency; 1.7.6 Resolution; References; 2 HPLC Theory; 2.1 Introduction; 2.2 Basic Chromatographic Descriptors; 2.3 Efficiency; 2.4 Resolution; 2.5 HPLC Retention; 2.6 Retention Mechanism; 2.7 General Column Mass Balance; 2.8 Partitioning Model; 2.9 Adsorption Model; 2.10 Total and Excess Adsorption; 2.11 Mass Balance in Adsorption Model; 2.12 Adsorption of the Eluent Components; 2.13 Void Volume Considerations; 2.14 Thermodynamic Relationships; 2.14.1 Effect of the Eluent Composition 327 $a2.15 Adsorption-Partitioning Retention Mechanism2.16 Secondary Equilibria; 2.16.1 Inclusion of Secondary Equilibria in the Mass Balance; 2.16.2 Salt Effect; 2.17 Gradient Elution Principles; 2.18 Types of Analyte Interactions with the Stationary Phase; 2.19 Conclusion; References; 3 Stationary Phases; 3.1 Introduction; 3.2 Type of Packing Material (Porous, Nonporous, Monolithic); 3.3 Base Material (Silica, Zirconia, Alumina, Polymers); 3.4 Geometry; 3.4.1 Shape (Spherical/Irregular); 3.4.2 Particle Size Distribution; 3.4.3 Surface Area; 3.4.4 Pore Volume; 3.4.5 Surface Geometry 327 $a3.5 Adsorbent Surface Chemistry3.5.1 Surface Chemistry of the Base Material; 3.5.2 Silica; 3.5.3 Silica Hybrid; 3.5.4 Polymeric Packings; 3.5.5 Zirconia (Metal Oxides); 3.5.6 Porous Carbon (or Carbon-Coated Phases); 3.6 Surface of Chemically Modified Material; 3.6.1 Limits of Surface Modification; 3.6.2 Chemical Modification; 3.6.3 Types of Bonded Phases; 3.6.4 Structure of the Bonded Layer; 3.6.5 Density of Bonded Ligands; 3.6.6 Residual Silanoles; 3.6.7 Surface Area of Modified Adsorbent; 3.7 Polymer-Based Adsorbents; 3.8 Stationary Phases for Chiral Separations 327 $a3.8.1 Polysaccharide-Coated Phases3.8.2 Pirkle-Type Phases; 3.8.3 Protein Phases; 3.8.4 Molecular Imprinted Polymers for Chiral Separations; 3.9 Columns; 3.9.1 Capillary/Monolithic/Packed Columns; 3.9.2 Column Cleaning; 3.9.3 Column Void Volume; 3.9.4 Mass of Adsorbent in the Column; References; 4 Reversed-Phase HPLC; 4.1 Introduction; 4.2 Retention in Reversed-Phase HPLC; 4.3 Stationary Phases for RPLC; 4.4 Mobile Phases for RPLC; 4.4.1 Eluent Composition and Solvent Strength of the Mobile Phase; 4.4.2 Type of Organic Modifier 327 $a4.4.3 Selectivity as a Function of Type and Concentration of Organic Composition 330 $aHPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Pr 606 $aHigh performance liquid chromatography 606 $aDrugs$xAnalysis 606 $aClinical chemistry 608 $aElectronic books. 615 0$aHigh performance liquid chromatography. 615 0$aDrugs$xAnalysis. 615 0$aClinical chemistry. 676 $a615.19 676 $a615.1901 676 $a615/.1901 701 $aKazakevich$b Yuri$0922091 701 $aLoBrutto$b Rosario$0922092 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143582603321 996 $aHPLC for pharmaceutical scientists$92069203 997 $aUNINA LEADER 05646nam 2200661 450 001 9910131364703321 005 20230621135907.0 010 $a9782889196180 (ebook) 035 $a(CKB)3710000000496798 035 $a(SSID)ssj0001680274 035 $a(PQKBManifestationID)16496258 035 $a(PQKBTitleCode)TC0001680274 035 $a(PQKBWorkID)15028457 035 $a(PQKB)10694358 035 $a(WaSeSS)IndRDA00057590 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46270 035 $a(EXLCZ)993710000000496798 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEmerging zoonoses $eeco-epidemiology, involved mechanisms and public health implications /$fedited by Rubén Bueno-Marí, A. Paulo Gouveia Almeida and Juan Carlos Navarro 210 $cFrontiers Media SA$d2015 210 31$aSwitzerland :$cFrontiers Media SA,$d2015 215 $a1 online resource (248 pages) $cillustrations 225 0 $aFrontiers Research Topics,$x1664-8714 300 $aBibliographic Level Mode of Issuance: Monograph 330 $aZoonoses are currently considered as one of the most important threats for Public Health worldwide. Zoonoses can be defined as any disease or infection that is naturally transmissible from vertebrate or invertebrate animals to humans and vice-versa. Approximately 75% of recently emerging infectious diseases affecting humans are diseases of animal origin; approximately 60% of all human pathogens are zoonotic. All types of potential pathogenic agents, including viruses, parasites, bacteria and fungi, can cause these zoonotic infections. From the wide range of potential vectors of zoonoses, insects are probably those of major significance due to their abundance, high plasticity and adaptability to different kinds of pathogens, high degrees of synanthropism in several groups and difficulties to apply effective programs of population control. Although ticks, flies, cockroaches, bugs and fleas are excellent insects capable to transmit viruses, parasites and bacteria, undoubtedly mosquitoes are the most important disease vectors. Mosquito borne diseases like malaria, dengue, equine encephalitis, West Nile, Mayaro or Chikungunya are zoonoses with increasing incidence in last years in tropical and temperate countries. Vertebrates can also transmit serious zoonoses, highlighting the role of some carnivorous animals in rabies dissemination or the spread of rodent borne diseases in several rural and urban areas. Moreover, the significance of other food borne zoonoses such as taeniasis, trichinellosis or toxoplasmosis may not been underestimated.According to WHO, FAO and OIE guidelines an emerging zoonotic disease can be defined asa zoonosis that is newly recognized or newly evolved, or that has occurred previously but shows an increase of incidence or expansion in geographical, host or vector range. There are many factors that can provoke or accelerate the emergence of zoonoses, such as environmental changes, habitat modifications, variations of human and animal demography, pathogens and vectors anomalous mobilization related with human practices and globalization, deterioration of the strategies of vector control or changes in pathogen genetics. To reduce Public Health risks from zoonoses is absolutely necessary to acquire an integrative perspective that includes the study of the complexity of interactions among humans, animals and environment in order to be able to fight against these issues of primary interest for human health. In any case, although zoonoses represent significant Public Health threats, many of them still remain as neglected diseases and consequently are not prioritized by some health international organisms.The aim of this Research Topic is to cover all related fields with zoonoses, including basic and applied researches, approaches to control measures, explanations of new theories or observations, opinion articles, reviews, etc. To deeply discuss these issues, a holistic and integrative point of view is obviously needed and guided by the ?One Health? strategy. Consequently the ambitious goal of this Research Topic will be only achieved by the collaboration of researchers specialized in different fields as medical and veterinary entomologists, parasitologists, veterinarians, virologists, zoologists, microbiologists, ecologists, evolutionary biologists and medicals specialized in epidemiology and public health. The participation of multiple contributors will be very important to comply with a knowledge demand of this issue of first-rate of scientific and medical interest. 606 $aZoonoses 606 $aTransmission of Disease$2HILCC 606 $aPublic Health$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $atrypanosomatids 610 $aepidemiology 610 $aBorrelia 610 $aone health 610 $aemerging infectious diseases 610 $avector borne diseases 610 $aBrucella 610 $azoonoses 610 $arickettsiae 610 $aarbovirus 615 12$aZoonoses. 615 7$aTransmission of Disease 615 7$aPublic Health 615 7$aHealth & Biological Sciences 676 $a614.5/6 700 $aA. Paulo Gouveia Almeida$4auth$01365340 702 $aNavarro$b Juan Carlos 702 $aBueno-Marí$b Rubén 702 $aAlmeida$b A. Paulo Gouveia 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910131364703321 996 $aEmerging zoonoses$93387147 997 $aUNINA