LEADER 02498nam 2200553 a 450 001 9910130843903321 005 20170816141826.0 010 $a1-283-14059-4 010 $a9786613140593 010 $a3-527-63332-4 010 $a3-527-63333-2 010 $a3-527-32636-7 035 $a(CKB)3440000000000192 035 $a(EBL)700916 035 $a(OCoLC)769341547 035 $a(SSID)ssj0000507333 035 $a(PQKBManifestationID)11358727 035 $a(PQKBTitleCode)TC0000507333 035 $a(PQKBWorkID)10545725 035 $a(PQKB)11551529 035 $a(MiAaPQ)EBC700916 035 $a(EXLCZ)993440000000000192 100 $a20120111d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVirtual screening$b[electronic resource] $eprinciples, challenges, and practical guidelines /$fedited by Christoph Sotriffer 210 $aWeinheim $cWiley-VCH$d2011 215 $a1 online resource (551 p.) 225 1 $aMethods and principles in medicinal chemistry ;$vv. 48 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references and index. 327 $apt. 1. Principles -- pt. 2. Challenges -- pt. 3. Applications and practical guidelines -- pt. 4. Scenarios and case studies : routes to success. 330 $aDrug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to ""real"" screening that requires 410 0$aMethods and principles in medicinal chemistry ;$vv. 48. 606 $aHigh throughput screening (Drug development)$xComputer simulation 608 $aElectronic books. 615 0$aHigh throughput screening (Drug development)$xComputer simulation. 676 $a615.1900113 701 $aSotriffer$b Christoph$0923337 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910130843903321 996 $aVirtual screening$92072102 997 $aUNINA LEADER 02984oam 2200697I 450 001 9910782535003321 005 20230808210401.0 010 $a1-351-89581-8 010 $a1-351-89582-6 010 $a1-315-24169-2 010 $a1-281-89418-4 010 $a9786611894184 010 $a0-7546-8991-3 024 7 $a10.4324/9781315241692 035 $a(CKB)1000000000578677 035 $a(EBL)438772 035 $a(OCoLC)297819994 035 $a(SSID)ssj0000256359 035 $a(PQKBManifestationID)11195847 035 $a(PQKBTitleCode)TC0000256359 035 $a(PQKBWorkID)10218792 035 $a(PQKB)11291446 035 $a(MiAaPQ)EBC438772 035 $a(Au-PeEL)EBL438772 035 $a(CaPaEBR)ebr10263899 035 $a(CaONFJC)MIL189418 035 $a(OCoLC)973034507 035 $a(EXLCZ)991000000000578677 100 $a20180706e20162008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTechnical change and economic growth $einside the knowledge based economy /$fGeorge M. Korres 205 $a2nd ed. 210 1$aLondon ;$aNew York :$cRoutledge,$d2016. 215 $a1 online resource (393 p.) 300 $aDescription based upon print version of record. 311 $a1-84014-992-2 320 $aIncludes bibliographical references and index. 327 $aCover; Contents; List of Figures; List of Tables; Preface; List of Abbreviations; 1 Knowledge Economy and Innovation Activities: An Approach to Definitions and Measurement; 2 Modelling Knowledge Economy and Innovation Activities with the Context of New Growth Theory; 3 Knowledge Economy, Technical Change and Productivity Growth; 4 Foreign Direct Investment (FDIs), National System of Innovations and Diffusion of Knowledge; 5 European Innovation Policy and Regional Cohesion; Appendix: Glossary of Definitions and Measurements; Bibliography; Index 330 $aIn this in-depth and detailed study, George Korres analyzes the macroeconomic and the microeconomic factors influencing the economics of innovation and the economic relations between technology, innovation, knowledge and productivity. 606 $aTechnological innovations$xEconomic aspects$zEuropean Union countries 606 $aTechnological innovations$xEconomic aspects$zGreece 606 $aProduction functions (Economic theory) 607 $aEuropean Union countries$xEconomic conditions 607 $aGreece$xEconomic conditions$y1974- 615 0$aTechnological innovations$xEconomic aspects 615 0$aTechnological innovations$xEconomic aspects 615 0$aProduction functions (Economic theory) 676 $a338' .064'094 676 $a338/.064094 700 $aKorres$b George M.$0146667 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782535003321 996 $aTechnical change and economic growth$93800378 997 $aUNINA